Timing of onset of lithium relapse prevention in bipolar disorder: Evidence from randomised trials

Matthew J. Taylor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Lithium is widely prescribed, but the timing of key effects remains uncertain. The timing of onset of its relapse prevention effects is clarified by placebo-controlled randomised trials (3 studies, n = 1120). Lithium reduced relapse into any mood episode over the first 2 weeks of treatment (hazard ratio 0.40, 95% CI 0.16-0.97). Fewer manic relapses were evident within the first 4 weeks, however, early effects on depressive relapse were not demonstrated. There is an early onset of lithium relapse prevention effects in bipolar disorder, particularly against manic relapse. Full effects against depressive relapse may develop over a longer period. Declaration of interest M.J.T. reports personal fees from Sunovion, Otsuka, Lundbeck, outside the submitted work.

Original languageEnglish
Pages (from-to)664-666
Number of pages3
JournalBritish Journal of Psychiatry
Volume213
Issue number5
Early online date2018
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Bipolar affective disorders
  • mood stabilisers
  • randomized controlled trial

Fingerprint

Dive into the research topics of 'Timing of onset of lithium relapse prevention in bipolar disorder: Evidence from randomised trials'. Together they form a unique fingerprint.

Cite this