Tissue architecture in tumor initiation and progression

TY - JOUR

T1 - Tissue architecture in tumor initiation and progression

AU - Almagro, Jorge

AU - Messal, Hendrik A.

AU - Elosegui-Artola, Alberto

AU - van Rheenen, Jacco

AU - Behrens, Axel

N1 - Funding Information: We are grateful to K. Ng (The Francis Crick Institute) for critical reading of the manuscript, and to C. Basier (The Francis Crick Institute) and K. Hansson (Institute of Cancer Research) for discussion of the relevant literature. This work was supported by the Francis Crick Institute , which receives its core funding from Cancer Research UK ( FC001039 , FC001317 , C38317 ), the UK Medical Research Council ( FC001039 , FC001317 ) and the Wellcome Trust ( FC001039 , FC001317 ), the Breast Cancer Now Toby Robins Research Centre at the Institute of Cancer Research ( CTR-Q5-Y2 ), and by KWF Kankerbestrijding ( A24043 ). Publisher Copyright: © 2022 The Authors

PY - 2022/6

Y1 - 2022/6

N2 - The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells.

AB - The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells.

KW - mechanics

KW - tissue architecture

KW - tumor progression

KW - tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=85126357169&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2022.02.007

DO - 10.1016/j.trecan.2022.02.007

M3 - Article

AN - SCOPUS:85126357169

SN - 2405-8033

VL - 8

SP - 494

EP - 505

JO - Trends in Cancer

JF - Trends in Cancer

IS - 6

ER -