Tissue saturation measurement - exciting prospects, but standardisation and reference data still needed

TY - JOUR

T1 - Tissue saturation measurement - exciting prospects, but standardisation and reference data still needed

AU - Jones, Nicola

AU - Terblanche, Marius

PY - 2010/6/24

Y1 - 2010/6/24

N2 - Sepsis and shock result in disturbances in microcirculatory perfusion and tissue oxygen utilisation that may not be reflected in global measures of haemodynamics. Near-infrared spectroscopy enables measurement of tissue oxygen saturation (StO(2)) and provides information on local microvascular and mitochondrial function. This measure could be incorporated with existing targets of goal-directed therapy to provide an integrated approach to haemodynamic resuscitation of both the macro- and microcirculation in various shock states. However, key methodological factors must be addressed before widespread clinical application.

AB - Sepsis and shock result in disturbances in microcirculatory perfusion and tissue oxygen utilisation that may not be reflected in global measures of haemodynamics. Near-infrared spectroscopy enables measurement of tissue oxygen saturation (StO(2)) and provides information on local microvascular and mitochondrial function. This measure could be incorporated with existing targets of goal-directed therapy to provide an integrated approach to haemodynamic resuscitation of both the macro- and microcirculation in various shock states. However, key methodological factors must be addressed before widespread clinical application.

KW - SEPTIC PATIENTS

KW - O-2 SATURATION

KW - MUSCLE STO(2)

KW - SHOCK

KW - SEPSIS

U2 - 10.1186/cc8970

DO - 10.1186/cc8970

M3 - Editorial

SN - 1466-609X

VL - 14

JO - CRITICAL CARE

JF - CRITICAL CARE

IS - 3

M1 - 169

ER -