Topical therapies for skin cancer and actinic keratosis

Tasnuva Haque; Khondaker M. Rahman; David E. Thurston; Jonathan Hadgraft; Majella E. Lane

doi:10.1016/j.ejps.2015.06.013

Topical therapies for skin cancer and actinic keratosis

Tasnuva Haque, Khondaker M. Rahman, David E. Thurston, Jonathan Hadgraft, Majella E. Lane^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The global incidence of skin cancer and actinic keratosis (AK) has increased dramatically in recent years. Although many tumours are treated with surgery or radiotherapy topical therapy has a place in the management of certain superficial skin neoplasms and AK. This review considers skin physiology, non-melanoma skin cancer (NMSC), the relationship between AK and skin cancer and drugs administered topically for these conditions. The dermal preparations for management of NMSC and AK are discussed in detail. Notably few studies have examined drug disposition in cancerous skin or in AK. Finally, recent novel approaches for targeting of drugs to skin neoplasms and AK are discussed.

Original language	English
Article number	3297
Pages (from-to)	279-289
Number of pages	11
Journal	EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume	77
DOIs	https://doi.org/10.1016/j.ejps.2015.06.013
Publication status	Published - 18 Sept 2015

Keywords

Actinic keratosis
Cancer
Formulation
Melanoma
Skin
Topical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejps.2015.06.013

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title = "Topical therapies for skin cancer and actinic keratosis",

abstract = "The global incidence of skin cancer and actinic keratosis (AK) has increased dramatically in recent years. Although many tumours are treated with surgery or radiotherapy topical therapy has a place in the management of certain superficial skin neoplasms and AK. This review considers skin physiology, non-melanoma skin cancer (NMSC), the relationship between AK and skin cancer and drugs administered topically for these conditions. The dermal preparations for management of NMSC and AK are discussed in detail. Notably few studies have examined drug disposition in cancerous skin or in AK. Finally, recent novel approaches for targeting of drugs to skin neoplasms and AK are discussed.",

keywords = "Actinic keratosis, Cancer, Formulation, Melanoma, Skin, Topical",

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T1 - Topical therapies for skin cancer and actinic keratosis

AU - Haque, Tasnuva

AU - Rahman, Khondaker M.

AU - Thurston, David E.

AU - Hadgraft, Jonathan

AU - Lane, Majella E.

PY - 2015/9/18

Y1 - 2015/9/18

N2 - The global incidence of skin cancer and actinic keratosis (AK) has increased dramatically in recent years. Although many tumours are treated with surgery or radiotherapy topical therapy has a place in the management of certain superficial skin neoplasms and AK. This review considers skin physiology, non-melanoma skin cancer (NMSC), the relationship between AK and skin cancer and drugs administered topically for these conditions. The dermal preparations for management of NMSC and AK are discussed in detail. Notably few studies have examined drug disposition in cancerous skin or in AK. Finally, recent novel approaches for targeting of drugs to skin neoplasms and AK are discussed.

AB - The global incidence of skin cancer and actinic keratosis (AK) has increased dramatically in recent years. Although many tumours are treated with surgery or radiotherapy topical therapy has a place in the management of certain superficial skin neoplasms and AK. This review considers skin physiology, non-melanoma skin cancer (NMSC), the relationship between AK and skin cancer and drugs administered topically for these conditions. The dermal preparations for management of NMSC and AK are discussed in detail. Notably few studies have examined drug disposition in cancerous skin or in AK. Finally, recent novel approaches for targeting of drugs to skin neoplasms and AK are discussed.

KW - Actinic keratosis

KW - Cancer

KW - Formulation

KW - Melanoma

KW - Skin

KW - Topical

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DO - 10.1016/j.ejps.2015.06.013

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SN - 0928-0987

VL - 77

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JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

M1 - 3297

ER -

Topical therapies for skin cancer and actinic keratosis

Abstract

Keywords

UN SDGs

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