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Topographically guided hierarchical mineralization

Research output: Contribution to journalArticlepeer-review

X Deng, A Hasan, Sherif Elsharkawy, Esther Tejeda-Montes, Nadezda V. Tarakina, G Greco, E Nikulina, JM Stormonth-Darling, N Convery, Jose C. Rodriguez-Cabello, A. Boyde, N Gadegaard, Nicola M. Pugno, Maisoon Al-Jawad, Alvaro Mata

Original languageEnglish
JournalMaterials Today Bio
Accepted/In press2 Jun 2021

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Abstract

Material platforms based on interaction between organic and inorganic phases offer enormous potential to
develop materials that can recreate the structural and functional properties of biological systems. However,
the capability of organic-mediated mineralizing strategies to guide mineralization with spatial control remains a major limitation. Here, we report on the integration of a protein-based mineralizing matrix with surface topographies to grow spatially guided mineralized structures. We reveal how well-defined geometrical
spaces defined within the organic matrix by the surface topographies can trigger subtle changes in single
nanocrystal co-alignment, which are then translated to drastic changes in mineralization at the microscale
and macroscale. Furthermore, through systematic modifications of the surface topographies, we demonstrate the possibility of selectively guiding the growth of hierarchically mineralized structures. We foresee
that the capacity to direct the anisotropic growth of such structures would offerhave important implications
in the design of biomineralizing synthetic materials to repair or regenerate hard tissues.

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