Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI

TY - JOUR

T1 - Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI

AU - Adler, Sophie

AU - Lorio, Sara

AU - Jacques, Thomas S

AU - Benova, Barbora

AU - Gunny, Roxana

AU - Cross, J Helen

AU - Baldeweg, Torsten

AU - Carmichael, David W

PY - 2017

Y1 - 2017

N2 - Focal cortical dysplasias (FCDs) are a range of malformations of cortical development each with specific histopathological features. Conventional radiological assessment of standard structural MRI is useful for the localization of lesions but is unable to accurately predict the histopathological features. Quantitative MRI offers the possibility to probe tissue biophysical properties in vivo and may bridge the gap between radiological assessment and ex-vivo histology. This review will cover histological, genetic and radiological features of FCD following the ILAE classification and will explain how quantitative voxel- and surface-based techniques can characterise these features. We will provide an overview of the quantitative MRI measures available, their link with biophysical properties and finally the potential application of quantitative MRI to the problem of FCD subtyping. Future research linking quantitative MRI to FCD histological properties should improve clinical protocols, allow better characterisation of lesions in vivo and tailored surgical planning to the individual.

AB - Focal cortical dysplasias (FCDs) are a range of malformations of cortical development each with specific histopathological features. Conventional radiological assessment of standard structural MRI is useful for the localization of lesions but is unable to accurately predict the histopathological features. Quantitative MRI offers the possibility to probe tissue biophysical properties in vivo and may bridge the gap between radiological assessment and ex-vivo histology. This review will cover histological, genetic and radiological features of FCD following the ILAE classification and will explain how quantitative voxel- and surface-based techniques can characterise these features. We will provide an overview of the quantitative MRI measures available, their link with biophysical properties and finally the potential application of quantitative MRI to the problem of FCD subtyping. Future research linking quantitative MRI to FCD histological properties should improve clinical protocols, allow better characterisation of lesions in vivo and tailored surgical planning to the individual.

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Malformations of Cortical Development/diagnostic imaging

KW - Phenotype

U2 - 10.1016/j.nicl.2017.04.017

DO - 10.1016/j.nicl.2017.04.017

M3 - Review article

C2 - 28491496

SN - 2213-1582

VL - 15

SP - 95

EP - 105

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

ER -