Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

TY - JOUR

T1 - Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents

T2 - a position paper of the ESC Working Group on Myocardial Function

AU - Zacchigna, Serena

AU - Paldino, Alessia

AU - Falcão-Pires, Inês

AU - Daskalopoulos, Evangelos P.

AU - Dal Ferro, Matteo

AU - Vodret, Simone

AU - Lesizza, Pierluigi

AU - Cannatà, Antonio

AU - Miranda-Silva, Daniela

AU - Lourenço, André P.

AU - Pinamonti, Bruno

AU - Sinagra, Gianfranco

AU - Weinberger, Florian

AU - Eschenhagen, Thomas

AU - Carrier, Lucie

AU - Kehat, Izhak

AU - Tocchetti, Carlo G.

AU - Russo, Michele

AU - Ghigo, Alessandra

AU - Cimino, James

AU - Hirsch, Emilio

AU - Dawson, Dana

AU - Ciccarelli, Michele

AU - Oliveti, Marco

AU - Linke, Wolfgang A.

AU - Cuijpers, Ilona

AU - Heymans, Stephane

AU - Hamdani, Nazha

AU - de Boer, Martine

AU - Duncker, Dirk J.

AU - Kuster, Diederik

AU - van der Velden, Jolanda

AU - Beauloye, Christophe

AU - Bertrand, Luc

AU - Mayr, Manuel

AU - Giacca, Mauro

AU - Leuschner, Florian

AU - Backs, Johannes

AU - Thum, Thomas

N1 - Publisher Copyright: © 2020 Published on behalf of the European Society of Cardiology. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.

AB - Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.

KW - Animal models

KW - Diastolic function

KW - Echocardiography

KW - Standardization

KW - Systolic function

UR - http://www.scopus.com/inward/record.url?scp=85099721822&partnerID=8YFLogxK

U2 - 10.1093/cvr/cvaa110

DO - 10.1093/cvr/cvaa110

M3 - Review article

C2 - 32365197

AN - SCOPUS:85099721822

SN - 0008-6363

VL - 117

SP - 43

EP - 59

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 1

ER -