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Towards ultrathin fiber-optic probe for simultaneous photoacoustic and fluorescence endoscopy

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Original languageEnglish
Title of host publication2021 IEEE International Ultrasonics Symposium (IUS)
Number of pages4
Published16 Nov 2021

Publication series

NameIEEE International Ultrasonics Symposium, IUS
PublisherI E E E
ISSN (Print)1948-5719

Bibliographical note

Funding Information: This project was supported by the Academy of Medical Sciences/the Wellcome Trust/ the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award [SBF006/1136], Wellcome Trust (203148/Z/16/Z, WT101957) and Engineering and Physical Sciences Research Council (NS/A000027/1, NS/A000049/1). Publisher Copyright: © 2021 IEEE.


  • Letter_2

    Letter_2.pdf, 1.31 MB, application/pdf

    Uploaded date:18 Nov 2021

    Version:Accepted author manuscript

King's Authors


A dual-modal photoacoustic and fluorescence endoscopy probe based on a single multimode fiber with a diameter of 140m was developed. By using a digital micromirror device with a high-speed algorithm for modulating the incident optical wavefront, the light transmission distortion through a multimode fiber was characterized and thus a focused laser beam was scanned at the distal fiber tip for microscopy imaging. Evaluation of the imaging performance was conducted with a dual-modal phantom comprising carbon fibers and fluorescence beads, and mouse red blood cells. The imaging probe has the potential to be further miniaturized using a fiber-optic ultrasound sensor so that it could be integrated into surgical tools such as medical needles for the guidance of minimally invasive procedures.

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