King's College London

Research portal

Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions

Research output: Contribution to journalArticle

Standard

Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. / Rivas, Charlotte; Stasiuk, Graeme J.; Sae-Heng, Myra; Long, Nicholas J.

In: Dalton Transactions, Vol. 44, No. 11, 2015, p. 4976-4985.

Research output: Contribution to journalArticle

Harvard

Rivas, C, Stasiuk, GJ, Sae-Heng, M & Long, NJ 2015, 'Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions', Dalton Transactions, vol. 44, no. 11, pp. 4976-4985. https://doi.org/10.1039/c4dt02981j

APA

Rivas, C., Stasiuk, G. J., Sae-Heng, M., & Long, N. J. (2015). Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton Transactions, 44(11), 4976-4985. https://doi.org/10.1039/c4dt02981j

Vancouver

Rivas C, Stasiuk GJ, Sae-Heng M, Long NJ. Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton Transactions. 2015;44(11):4976-4985. https://doi.org/10.1039/c4dt02981j

Author

Rivas, Charlotte ; Stasiuk, Graeme J. ; Sae-Heng, Myra ; Long, Nicholas J. / Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. In: Dalton Transactions. 2015 ; Vol. 44, No. 11. pp. 4976-4985.

Bibtex Download

@article{790ceb9969ba4ab68bd6a298b369fc57,
title = "Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions",
abstract = "A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and a slight blue-shift in fluorescence in the presence of zinc; however, a decrease in relaxation rate was observed. Consequently, the ability of the well-known zinc chelator, BPEN, was assessed for relaxivity response when conjugated to the gadolinium chelate. The success of this probe [GdL2], lead to the inclusion of the same zinc-probing moiety alongside a longer wavelength emitting fluorophore, rhodamine [GdL3], to arrive at the final iteration of these first generation dual-modal zinc-sensing probes. The compounds give insight into the design protocols required for the successful imaging of zinc ions. This journal is",
author = "Charlotte Rivas and Stasiuk, {Graeme J.} and Myra Sae-Heng and Long, {Nicholas J.}",
year = "2015",
doi = "10.1039/c4dt02981j",
language = "English",
volume = "44",
pages = "4976--4985",
journal = "Dalton transactions (Cambridge, England : 2003)",
issn = "1477-9226",
number = "11",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions

AU - Rivas, Charlotte

AU - Stasiuk, Graeme J.

AU - Sae-Heng, Myra

AU - Long, Nicholas J.

PY - 2015

Y1 - 2015

N2 - A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and a slight blue-shift in fluorescence in the presence of zinc; however, a decrease in relaxation rate was observed. Consequently, the ability of the well-known zinc chelator, BPEN, was assessed for relaxivity response when conjugated to the gadolinium chelate. The success of this probe [GdL2], lead to the inclusion of the same zinc-probing moiety alongside a longer wavelength emitting fluorophore, rhodamine [GdL3], to arrive at the final iteration of these first generation dual-modal zinc-sensing probes. The compounds give insight into the design protocols required for the successful imaging of zinc ions. This journal is

AB - A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and a slight blue-shift in fluorescence in the presence of zinc; however, a decrease in relaxation rate was observed. Consequently, the ability of the well-known zinc chelator, BPEN, was assessed for relaxivity response when conjugated to the gadolinium chelate. The success of this probe [GdL2], lead to the inclusion of the same zinc-probing moiety alongside a longer wavelength emitting fluorophore, rhodamine [GdL3], to arrive at the final iteration of these first generation dual-modal zinc-sensing probes. The compounds give insight into the design protocols required for the successful imaging of zinc ions. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84924301145&partnerID=8YFLogxK

U2 - 10.1039/c4dt02981j

DO - 10.1039/c4dt02981j

M3 - Article

C2 - 25578943

AN - SCOPUS:84924301145

VL - 44

SP - 4976

EP - 4985

JO - Dalton transactions (Cambridge, England : 2003)

JF - Dalton transactions (Cambridge, England : 2003)

SN - 1477-9226

IS - 11

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454