Track-density imaging (TDI): Super-resolution white matter imaging using whole-brain track-density mapping

TY - JOUR

T1 - Track-density imaging (TDI)

T2 - Super-resolution white matter imaging using whole-brain track-density mapping

AU - Calamante, Fernando

AU - Tournier, Jacques-Donald

AU - Jackson, Graeme D.

AU - Connelly, Alan

PY - 2010/12

Y1 - 2010/12

N2 - Neuroimaging advances have given rise to major progress in neurosciences and neurology, as ever more subtle and specific imaging methods reveal new aspects of the brain. One major limitation of current methods is the spatial scale of the information available. We present an approach to gain spatial resolution using post-processing methods based on diffusion MRI fiber-tracking, to reveal structures beyond the resolution of the acquired imaging voxel: we term such a method as super-resolution track-density imaging (TDI). A major unmet challenge in imaging is the identification of abnormalities in white matter as a cause of illness; super-resolution TDI is shown to produce high-quality white matter images, with high spatial resolution and outstanding anatomical contrast. A unique property of these maps is demonstrated: their spatial resolution and signal-to-noise ratio can be tailored depending on the chosen image resolution and total number of fiber-tracks generated. Super-resolution TDI should greatly enhance the study of white matter in disorders of the brain and mind.

AB - Neuroimaging advances have given rise to major progress in neurosciences and neurology, as ever more subtle and specific imaging methods reveal new aspects of the brain. One major limitation of current methods is the spatial scale of the information available. We present an approach to gain spatial resolution using post-processing methods based on diffusion MRI fiber-tracking, to reveal structures beyond the resolution of the acquired imaging voxel: we term such a method as super-resolution track-density imaging (TDI). A major unmet challenge in imaging is the identification of abnormalities in white matter as a cause of illness; super-resolution TDI is shown to produce high-quality white matter images, with high spatial resolution and outstanding anatomical contrast. A unique property of these maps is demonstrated: their spatial resolution and signal-to-noise ratio can be tailored depending on the chosen image resolution and total number of fiber-tracks generated. Super-resolution TDI should greatly enhance the study of white matter in disorders of the brain and mind.

KW - Magnetic resonance imaging

KW - Super-resolution

KW - White matter

KW - Fiber-tracking

KW - Diffusion MRI

KW - IN-DIFFUSION MRI

KW - SPHERICAL DECONVOLUTION

KW - FIBER

KW - ORIENTATION

KW - TRACTOGRAPHY

KW - RESOLUTION

KW - TISSUES

KW - IMAGES

U2 - 10.1016/j.neuroimage.2010.07.024

DO - 10.1016/j.neuroimage.2010.07.024

M3 - Article

SN - 1053-8119

VL - 53

SP - 1233

EP - 1243

JO - NeuroImage

JF - NeuroImage

IS - 4

ER -