Tract-specific anisotropy measurements in diffusion tensor imaging

TY - JOUR

T1 - Tract-specific anisotropy measurements in diffusion tensor imaging

AU - Kanaan, R A

AU - Shergill, S S

AU - Barker, G J

AU - Catani, M

AU - Ng, V W

AU - Howard, R J

AU - McGuire, P K

AU - Jones, D K

PY - 2006/1/30

Y1 - 2006/1/30

N2 - Diffusion tensor magnetic resonance imaging (DT-MRI) has been used to examine the microstructure of individual white matter tracts, often in neuropsychiatric conditions without identifiable focal pathology. However, the voxel-based group-mapping and region-of-interest (ROI) approaches used to analyse the data have inherent conceptual and practical difficulties. Taking the example of the genu of the corpus callosum in a sample of schizophrenic patients, we discuss the difficulties in attempting to replicate a voxel-based finding of reduced anisotropy using two ROI methods. Firstly we consider conventional ROIs; secondly, we present a novel tractography-based approach. The problems of both methods are explored, particularly of high variance and ROI definition. The potential benefits of the tractographic method for neuropsychiatric conditions with subtle and diffuse pathology are outlined. (c) 2005 Elsevier Ireland Ltd. All rights reserved

AB - Diffusion tensor magnetic resonance imaging (DT-MRI) has been used to examine the microstructure of individual white matter tracts, often in neuropsychiatric conditions without identifiable focal pathology. However, the voxel-based group-mapping and region-of-interest (ROI) approaches used to analyse the data have inherent conceptual and practical difficulties. Taking the example of the genu of the corpus callosum in a sample of schizophrenic patients, we discuss the difficulties in attempting to replicate a voxel-based finding of reduced anisotropy using two ROI methods. Firstly we consider conventional ROIs; secondly, we present a novel tractography-based approach. The problems of both methods are explored, particularly of high variance and ROI definition. The potential benefits of the tractographic method for neuropsychiatric conditions with subtle and diffuse pathology are outlined. (c) 2005 Elsevier Ireland Ltd. All rights reserved

U2 - 10.1016/j.pscychresns.2005.11.002

DO - 10.1016/j.pscychresns.2005.11.002

M3 - Article

VL - 146

SP - 73

EP - 82

JO - Psychiatry Research. Neuroimaging

JF - Psychiatry Research. Neuroimaging

IS - 1

ER -