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Trajectories of quality of life in early-stage dementia: individual variations and predictors of change

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Trajectories of quality of life in early-stage dementia : individual variations and predictors of change. / Clare, Linda; Woods, Robert T.; Nelis, Sharon M.; Martyr, Anthony; Markova, Ivana S.; Roth, Ilona; Whitaker, Christopher J.; Morris, Robin G.

In: International Journal of Geriatric Psychiatry, Vol. 29, No. 6, 06.2014, p. 616-623.

Research output: Contribution to journalArticle

Harvard

Clare, L, Woods, RT, Nelis, SM, Martyr, A, Markova, IS, Roth, I, Whitaker, CJ & Morris, RG 2014, 'Trajectories of quality of life in early-stage dementia: individual variations and predictors of change', International Journal of Geriatric Psychiatry, vol. 29, no. 6, pp. 616-623. https://doi.org/10.1002/gps.4044

APA

Clare, L., Woods, R. T., Nelis, S. M., Martyr, A., Markova, I. S., Roth, I., ... Morris, R. G. (2014). Trajectories of quality of life in early-stage dementia: individual variations and predictors of change. International Journal of Geriatric Psychiatry, 29(6), 616-623. https://doi.org/10.1002/gps.4044

Vancouver

Clare L, Woods RT, Nelis SM, Martyr A, Markova IS, Roth I et al. Trajectories of quality of life in early-stage dementia: individual variations and predictors of change. International Journal of Geriatric Psychiatry. 2014 Jun;29(6):616-623. https://doi.org/10.1002/gps.4044

Author

Clare, Linda ; Woods, Robert T. ; Nelis, Sharon M. ; Martyr, Anthony ; Markova, Ivana S. ; Roth, Ilona ; Whitaker, Christopher J. ; Morris, Robin G. / Trajectories of quality of life in early-stage dementia : individual variations and predictors of change. In: International Journal of Geriatric Psychiatry. 2014 ; Vol. 29, No. 6. pp. 616-623.

Bibtex Download

@article{7daf9e862e844327ae17f047bad51a89,
title = "Trajectories of quality of life in early-stage dementia: individual variations and predictors of change",
abstract = "Background Little evidence is available about how quality of life (QoL) changes as dementia progresses. Objectives We explored QoL trajectories over a 20-month period and examined what predicted change in QoL. Method Fifty-one individuals with a diagnosis of Alzheimer's, vascular or mixed dementia (people with dementia (PwD)) participating in the Memory Impairment and Dementia Awareness Study rated their QoL using the QoL-Alzheimer's Disease Scale at baseline and at 20-month follow-up. PwD also rated their mood and quality of relationship with the carer. In each case, the carer rated his or her level of stress and perceived quality of relationship with the PwD. Results There was no change in mean QoL score. Nearly one-third of PwD rated QoL more positively at 20-month follow-up and nearly one-third rated QoL more negatively. These changes could be regarded as reliable in one-quarter of the sample. Participants taking acetylcholinesterase-inhibiting medication at baseline were more likely to show a decline in QoL score. There were no other significant differences between those whose scores increased, decreased or stayed the same on any demographic or disease-related variables, or in mood or perceived quality of relationship with the carer. Whereas baseline QoL score was the strongest predictor of QoL at 20 months, the quality of relationship with the carer as perceived by the PwD was also independently a significant predictor. Conclusions There is a degree of individual variation in QoL trajectories. Use of acetylcholinesterase-inhibiting medication appears linked to decline in QoL score, whereas positive relationships with carers play an important role in maintaining QoL in early-stage dementia.",
keywords = "Alzheimer's disease, caregiver, vascular dementia, depression, quality of relationship, ALZHEIMERS-DISEASE, OLDER-ADULTS, CARE, PEOPLE, PERSPECTIVE, DONEPEZIL, RATINGS, TRIAL",
author = "Linda Clare and Woods, {Robert T.} and Nelis, {Sharon M.} and Anthony Martyr and Markova, {Ivana S.} and Ilona Roth and Whitaker, {Christopher J.} and Morris, {Robin G.}",
year = "2014",
month = "6",
doi = "10.1002/gps.4044",
language = "English",
volume = "29",
pages = "616--623",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "WILEY-BLACKWELL",
number = "6",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Trajectories of quality of life in early-stage dementia

T2 - individual variations and predictors of change

AU - Clare, Linda

AU - Woods, Robert T.

AU - Nelis, Sharon M.

AU - Martyr, Anthony

AU - Markova, Ivana S.

AU - Roth, Ilona

AU - Whitaker, Christopher J.

AU - Morris, Robin G.

PY - 2014/6

Y1 - 2014/6

N2 - Background Little evidence is available about how quality of life (QoL) changes as dementia progresses. Objectives We explored QoL trajectories over a 20-month period and examined what predicted change in QoL. Method Fifty-one individuals with a diagnosis of Alzheimer's, vascular or mixed dementia (people with dementia (PwD)) participating in the Memory Impairment and Dementia Awareness Study rated their QoL using the QoL-Alzheimer's Disease Scale at baseline and at 20-month follow-up. PwD also rated their mood and quality of relationship with the carer. In each case, the carer rated his or her level of stress and perceived quality of relationship with the PwD. Results There was no change in mean QoL score. Nearly one-third of PwD rated QoL more positively at 20-month follow-up and nearly one-third rated QoL more negatively. These changes could be regarded as reliable in one-quarter of the sample. Participants taking acetylcholinesterase-inhibiting medication at baseline were more likely to show a decline in QoL score. There were no other significant differences between those whose scores increased, decreased or stayed the same on any demographic or disease-related variables, or in mood or perceived quality of relationship with the carer. Whereas baseline QoL score was the strongest predictor of QoL at 20 months, the quality of relationship with the carer as perceived by the PwD was also independently a significant predictor. Conclusions There is a degree of individual variation in QoL trajectories. Use of acetylcholinesterase-inhibiting medication appears linked to decline in QoL score, whereas positive relationships with carers play an important role in maintaining QoL in early-stage dementia.

AB - Background Little evidence is available about how quality of life (QoL) changes as dementia progresses. Objectives We explored QoL trajectories over a 20-month period and examined what predicted change in QoL. Method Fifty-one individuals with a diagnosis of Alzheimer's, vascular or mixed dementia (people with dementia (PwD)) participating in the Memory Impairment and Dementia Awareness Study rated their QoL using the QoL-Alzheimer's Disease Scale at baseline and at 20-month follow-up. PwD also rated their mood and quality of relationship with the carer. In each case, the carer rated his or her level of stress and perceived quality of relationship with the PwD. Results There was no change in mean QoL score. Nearly one-third of PwD rated QoL more positively at 20-month follow-up and nearly one-third rated QoL more negatively. These changes could be regarded as reliable in one-quarter of the sample. Participants taking acetylcholinesterase-inhibiting medication at baseline were more likely to show a decline in QoL score. There were no other significant differences between those whose scores increased, decreased or stayed the same on any demographic or disease-related variables, or in mood or perceived quality of relationship with the carer. Whereas baseline QoL score was the strongest predictor of QoL at 20 months, the quality of relationship with the carer as perceived by the PwD was also independently a significant predictor. Conclusions There is a degree of individual variation in QoL trajectories. Use of acetylcholinesterase-inhibiting medication appears linked to decline in QoL score, whereas positive relationships with carers play an important role in maintaining QoL in early-stage dementia.

KW - Alzheimer's disease

KW - caregiver

KW - vascular dementia

KW - depression

KW - quality of relationship

KW - ALZHEIMERS-DISEASE

KW - OLDER-ADULTS

KW - CARE

KW - PEOPLE

KW - PERSPECTIVE

KW - DONEPEZIL

KW - RATINGS

KW - TRIAL

U2 - 10.1002/gps.4044

DO - 10.1002/gps.4044

M3 - Article

VL - 29

SP - 616

EP - 623

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 6

ER -

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