Abstract
Mammalian innate lymphoid cells (ILC)s have functional relevance under both homeostatic and disease
settings such as inflammatory bowel disease and particularly in the context of maintaining the integrity of
mucosal surfaces. Early reports highlighted that type 1 and 3 ILC regulatory transcription factors (TF)s, T-bet
(Tbx21) and RORγt (Rorc) as key regulators of ILC biology. Since then, other canonical TFs have been shown
to play a role in the development and function of ILC subsets. In this review, we focus on recent insights into
the balance between mature ILC1 and ILC3 based on these TFs and how they interact with other key cell-intrinsic molecular pathways. We outline how this TF interplay might be explored to identify novel candidate
therapeutic avenues for human diseases.
settings such as inflammatory bowel disease and particularly in the context of maintaining the integrity of
mucosal surfaces. Early reports highlighted that type 1 and 3 ILC regulatory transcription factors (TF)s, T-bet
(Tbx21) and RORγt (Rorc) as key regulators of ILC biology. Since then, other canonical TFs have been shown
to play a role in the development and function of ILC subsets. In this review, we focus on recent insights into
the balance between mature ILC1 and ILC3 based on these TFs and how they interact with other key cell-intrinsic molecular pathways. We outline how this TF interplay might be explored to identify novel candidate
therapeutic avenues for human diseases.
| Original language | English |
|---|---|
| Journal | Trends in Immunology |
| Publication status | Accepted/In press - 29 Apr 2022 |