Transition metal mediated [C-11] carbonylation reactions: recent advances and applications

Steven Kealey; Antony Gee; Philip W. Miller

doi:10.1002/jlcr.3150

Transition metal mediated [C-11] carbonylation reactions: recent advances and applications

Steven Kealey, Antony Gee, Philip W. Miller^*

^*Corresponding author for this work

Imperial College London

Research output: Contribution to journal › Literature review › peer-review

61 Citations (Scopus)

Abstract

[C-11]Carbon monoxide is undoubtedly a highly versatile radiolabelling synthon with many potential applications for the synthesis of positron emission tomography (PET) tracer molecules and functional groups, but why has it not found more applications in the PET radiolabelling arena? Today, (CO)-C-11 radiolabelling is still primarily viewed as a niche area; however, there are signs that this is beginning to change as some of the technical and chemistry challenges of producing, handling and reacting (CO)-C-11 are overcome. This mini review covers the more recent developments of (CO)-C-11-labelling chemistry and is focused on palladium and rhodium-mediated carbonylation reactions that are growing in importance and finding wider application for carbon-11 PET radiotracer development.

Original language	English
Pages (from-to)	195-201
Number of pages	7
Journal	JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume	57
Issue number	4
DOIs	https://doi.org/10.1002/jlcr.3150
Publication status	Published - Apr 2014

Keywords

PET
carbon monoxide
(CO)-C-11
carbonylation
palladium
rhodium
POSITRON-EMISSION-TOMOGRAPHY
RHODIUM-PROMOTED CARBONYLATION
RADICAL CARBONYLATION
VERSATILE REAGENT
RECEPTOR-LIGAND
MONOXIDE
RADIOSYNTHESIS
RADIOTRACERS
DERIVATIVES
COMPLEXES

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title = "Transition metal mediated [C-11] carbonylation reactions: recent advances and applications",

abstract = "[C-11]Carbon monoxide is undoubtedly a highly versatile radiolabelling synthon with many potential applications for the synthesis of positron emission tomography (PET) tracer molecules and functional groups, but why has it not found more applications in the PET radiolabelling arena? Today, (CO)-C-11 radiolabelling is still primarily viewed as a niche area; however, there are signs that this is beginning to change as some of the technical and chemistry challenges of producing, handling and reacting (CO)-C-11 are overcome. This mini review covers the more recent developments of (CO)-C-11-labelling chemistry and is focused on palladium and rhodium-mediated carbonylation reactions that are growing in importance and finding wider application for carbon-11 PET radiotracer development.",

keywords = "PET, carbon monoxide, (CO)-C-11, carbonylation, palladium, rhodium, POSITRON-EMISSION-TOMOGRAPHY, RHODIUM-PROMOTED CARBONYLATION, RADICAL CARBONYLATION, VERSATILE REAGENT, RECEPTOR-LIGAND, MONOXIDE, RADIOSYNTHESIS, RADIOTRACERS, DERIVATIVES, COMPLEXES",

author = "Steven Kealey and Antony Gee and Miller, {Philip W.}",

year = "2014",

month = apr,

doi = "10.1002/jlcr.3150",

language = "English",

volume = "57",

pages = "195--201",

journal = "JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS",

issn = "0362-4803",

publisher = "John Wiley & Sons, Ltd",

number = "4",

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TY - JOUR

T1 - Transition metal mediated [C-11] carbonylation reactions

T2 - recent advances and applications

AU - Kealey, Steven

AU - Gee, Antony

AU - Miller, Philip W.

PY - 2014/4

Y1 - 2014/4

N2 - [C-11]Carbon monoxide is undoubtedly a highly versatile radiolabelling synthon with many potential applications for the synthesis of positron emission tomography (PET) tracer molecules and functional groups, but why has it not found more applications in the PET radiolabelling arena? Today, (CO)-C-11 radiolabelling is still primarily viewed as a niche area; however, there are signs that this is beginning to change as some of the technical and chemistry challenges of producing, handling and reacting (CO)-C-11 are overcome. This mini review covers the more recent developments of (CO)-C-11-labelling chemistry and is focused on palladium and rhodium-mediated carbonylation reactions that are growing in importance and finding wider application for carbon-11 PET radiotracer development.

AB - [C-11]Carbon monoxide is undoubtedly a highly versatile radiolabelling synthon with many potential applications for the synthesis of positron emission tomography (PET) tracer molecules and functional groups, but why has it not found more applications in the PET radiolabelling arena? Today, (CO)-C-11 radiolabelling is still primarily viewed as a niche area; however, there are signs that this is beginning to change as some of the technical and chemistry challenges of producing, handling and reacting (CO)-C-11 are overcome. This mini review covers the more recent developments of (CO)-C-11-labelling chemistry and is focused on palladium and rhodium-mediated carbonylation reactions that are growing in importance and finding wider application for carbon-11 PET radiotracer development.

KW - PET

KW - carbon monoxide

KW - (CO)-C-11

KW - carbonylation

KW - palladium

KW - rhodium

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - RHODIUM-PROMOTED CARBONYLATION

KW - RADICAL CARBONYLATION

KW - VERSATILE REAGENT

KW - RECEPTOR-LIGAND

KW - MONOXIDE

KW - RADIOSYNTHESIS

KW - RADIOTRACERS

KW - DERIVATIVES

KW - COMPLEXES

U2 - 10.1002/jlcr.3150

DO - 10.1002/jlcr.3150

M3 - Literature review

SN - 0362-4803

VL - 57

SP - 195

EP - 201

JO - JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

JF - JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

IS - 4

ER -

Transition metal mediated [C-11] carbonylation reactions: recent advances and applications

Abstract

Keywords

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