Transition metal mediated [C-11] carbonylation reactions: recent advances and applications

Steven Kealey, Antony Gee, Philip W. Miller*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

59 Citations (Scopus)

Abstract

[C-11]Carbon monoxide is undoubtedly a highly versatile radiolabelling synthon with many potential applications for the synthesis of positron emission tomography (PET) tracer molecules and functional groups, but why has it not found more applications in the PET radiolabelling arena? Today, (CO)-C-11 radiolabelling is still primarily viewed as a niche area; however, there are signs that this is beginning to change as some of the technical and chemistry challenges of producing, handling and reacting (CO)-C-11 are overcome. This mini review covers the more recent developments of (CO)-C-11-labelling chemistry and is focused on palladium and rhodium-mediated carbonylation reactions that are growing in importance and finding wider application for carbon-11 PET radiotracer development.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume57
Issue number4
DOIs
Publication statusPublished - Apr 2014

Keywords

  • PET
  • carbon monoxide
  • (CO)-C-11
  • carbonylation
  • palladium
  • rhodium
  • POSITRON-EMISSION-TOMOGRAPHY
  • RHODIUM-PROMOTED CARBONYLATION
  • RADICAL CARBONYLATION
  • VERSATILE REAGENT
  • RECEPTOR-LIGAND
  • MONOXIDE
  • RADIOSYNTHESIS
  • RADIOTRACERS
  • DERIVATIVES
  • COMPLEXES

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