Transitional B cell subsets – a convincing predictive biomarker for allograft loss?

TY - JOUR

T1 - Transitional B cell subsets – a convincing predictive biomarker for allograft loss?

AU - Burton, Hannah Marguerite Mckenna

AU - Dorling, Anthony

PY - 2017/1/1

Y1 - 2017/1/1

N2 - In this issue, Cherukuri and colleagues describe a convincing association between the proportion of transitional B lymphocyte subsets in kidney transplant recipients and long-term outcomes, and present a biologically plausible mechanism, based on differential ability of T1 and T2 cells to regulate in vitro T cell responses to explain the link. Further work is clearly needed to validate their claim that measurement of T1/T2 ratios may represent a reliable and reproducible predictive biomarker of transplant outcomes.

AB - In this issue, Cherukuri and colleagues describe a convincing association between the proportion of transitional B lymphocyte subsets in kidney transplant recipients and long-term outcomes, and present a biologically plausible mechanism, based on differential ability of T1 and T2 cells to regulate in vitro T cell responses to explain the link. Further work is clearly needed to validate their claim that measurement of T1/T2 ratios may represent a reliable and reproducible predictive biomarker of transplant outcomes.

M3 - Comment/debate

SN - 0085-2538

VL - 91

SP - 18

EP - 20

JO - Kidney International

JF - Kidney International

IS - 1

M1 - KI-09-16-1329

ER -