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Translational control of stem cell function

Research output: Contribution to journalReview articlepeer-review

James A Saba, Kifayathullah Liakath-Ali, Rachel Green, Fiona M Watt

Original languageEnglish
Pages (from-to)671-690
Number of pages20
JournalNature reviews. Molecular cell biology
Volume22
Issue number10
Early online date16 Jul 2021
DOIs
E-pub ahead of print16 Jul 2021
PublishedOct 2021

King's Authors

Abstract

Stem cells are characterized by their ability to self-renew and differentiate into many different cell types. Research has focused primarily on how these processes are regulated at a transcriptional level. However, recent studies have indicated that stem cell behaviour is strongly coupled to the regulation of protein synthesis by the ribosome. In this Review, we discuss how different translation mechanisms control the function of adult and embryonic stem cells. Stem cells are characterized by low global translation rates despite high levels of ribosome biogenesis. The maintenance of pluripotency, the commitment to a specific cell fate and the switch to cell differentiation depend on the tight regulation of protein synthesis and ribosome biogenesis. Translation regulatory mechanisms that impact on stem cell function include mTOR signalling, ribosome levels, and mRNA and tRNA features and amounts. Understanding these mechanisms important for stem cell self-renewal and differentiation may also guide our understanding of cancer grade and metastasis.

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