Transplant Accommodation: Are the Lessons Learned from Xenotransplantation Pertinent for Clinical Allotransplantation?

A. Dorling

doi:10.1111/j.1600-6143.2011.03821.x

Transplant Accommodation: Are the Lessons Learned from Xenotransplantation Pertinent for Clinical Allotransplantation?

A. Dorling

Research output: Contribution to journal › Literature review › peer-review

29 Citations (Scopus)

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Abstract

Accommodation refers to a vascularized transplant that has acquired resistance to antibody-mediated rejection (AMR). The term was coined in 1990, but the phenomenon was first described after clinical ABO-incompatible (ABOi) renal transplantation in the 1980s and is recognized as a common outcome in this context today. Because of the absence, until recently of reliable animal models of allograft accommodation, it has been studied extensively by investigators in the xenotransplantation field. With recent advances in the ability to recognize and diagnose AMR in human organs, the growth of desensitization programmes for transplantation into sensitized recipients and the availability of therapies that have the potential to promote accommodation, it is timely to review the literature in this area, identifying lessons that may inform preclinical and clinical studies in the future.

Original language	English
Pages (from-to)	545 - 553
Number of pages	9
Journal	American Journal of Transplantation
Volume	12
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-6143.2011.03821.x
Publication status	Published - Mar 2012

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title = "Transplant Accommodation: Are the Lessons Learned from Xenotransplantation Pertinent for Clinical Allotransplantation?",

abstract = "Accommodation refers to a vascularized transplant that has acquired resistance to antibody-mediated rejection (AMR). The term was coined in 1990, but the phenomenon was first described after clinical ABO-incompatible (ABOi) renal transplantation in the 1980s and is recognized as a common outcome in this context today. Because of the absence, until recently of reliable animal models of allograft accommodation, it has been studied extensively by investigators in the xenotransplantation field. With recent advances in the ability to recognize and diagnose AMR in human organs, the growth of desensitization programmes for transplantation into sensitized recipients and the availability of therapies that have the potential to promote accommodation, it is timely to review the literature in this area, identifying lessons that may inform preclinical and clinical studies in the future.",

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T2 - Are the Lessons Learned from Xenotransplantation Pertinent for Clinical Allotransplantation?

AU - Dorling, A.

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N2 - Accommodation refers to a vascularized transplant that has acquired resistance to antibody-mediated rejection (AMR). The term was coined in 1990, but the phenomenon was first described after clinical ABO-incompatible (ABOi) renal transplantation in the 1980s and is recognized as a common outcome in this context today. Because of the absence, until recently of reliable animal models of allograft accommodation, it has been studied extensively by investigators in the xenotransplantation field. With recent advances in the ability to recognize and diagnose AMR in human organs, the growth of desensitization programmes for transplantation into sensitized recipients and the availability of therapies that have the potential to promote accommodation, it is timely to review the literature in this area, identifying lessons that may inform preclinical and clinical studies in the future.

AB - Accommodation refers to a vascularized transplant that has acquired resistance to antibody-mediated rejection (AMR). The term was coined in 1990, but the phenomenon was first described after clinical ABO-incompatible (ABOi) renal transplantation in the 1980s and is recognized as a common outcome in this context today. Because of the absence, until recently of reliable animal models of allograft accommodation, it has been studied extensively by investigators in the xenotransplantation field. With recent advances in the ability to recognize and diagnose AMR in human organs, the growth of desensitization programmes for transplantation into sensitized recipients and the availability of therapies that have the potential to promote accommodation, it is timely to review the literature in this area, identifying lessons that may inform preclinical and clinical studies in the future.

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DO - 10.1111/j.1600-6143.2011.03821.x

M3 - Literature review

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JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 3

ER -

Transplant Accommodation: Are the Lessons Learned from Xenotransplantation Pertinent for Clinical Allotransplantation?

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