Transposable Elements Re-Wire and Fine-Tune the Transcriptome

Michael Cowley*, Rebecca J. Oakey

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

158 Citations (Scopus)

Abstract

What good are transposable elements (TEs)? Although their activity can be harmful to host genomes and can cause disease, they nevertheless represent an important source of genetic variation that has helped shape genomes. In this review, we examine the impact of TEs, collectively referred to as the mobilome, on the transcriptome. We explore how TEs-particularly retro-transposons-contribute to transcript diversity and consider their potential significance as a source of small RNAs that regulate host gene transcription. We also discuss a critical role for the mobilome in engineering transcriptional networks, permitting coordinated gene expression, and facilitating the evolution of novel physiological processes.

Original languageEnglish
Article numbere1003234
Pages (from-to)N/A
Number of pages7
JournalPL o S Genetics
Volume9
Issue number1
DOIs
Publication statusPublished - 24 Jan 2013

Keywords

  • EMBRYONIC STEM-CELLS
  • HUMAN GENOME
  • ENDOGENOUS RETROVIRUSES
  • L1 RETROTRANSPOSITION
  • DNA METHYLATION
  • LINE-1 RETROTRANSPOSITION
  • EPIGENETIC INHERITANCE
  • GENE-EXPRESSION
  • GERM-CELLS
  • ALU EXONS

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