TY - JOUR
T1 - Trazodone in the Management of Major Depression Among Elderly Patients with Dementia
T2 - A Narrative Review and Clinical Insights
AU - Fagiolini, Andrea
AU - González Pinto, Ana
AU - Miskowiak, Kamilla Woznica
AU - Morgado, Pedro
AU - Young, Allan H
AU - Vieta, Eduard
N1 - © 2023 Fagiolini et al.
PY - 2023
Y1 - 2023
N2 - OBJECTIVE: Major depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.RESULTS: Because of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impairment, and irritability.CONCLUSION: Trazodone may be beneficial for patients with dementia or other neurological disorders comorbid with MDD, especially when the clinical picture of depression includes or is comorbid to symptoms of insomnia, irritability, inner tension, anxiety, or psychomotor agitation.
AB - OBJECTIVE: Major depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.RESULTS: Because of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impairment, and irritability.CONCLUSION: Trazodone may be beneficial for patients with dementia or other neurological disorders comorbid with MDD, especially when the clinical picture of depression includes or is comorbid to symptoms of insomnia, irritability, inner tension, anxiety, or psychomotor agitation.
U2 - 10.2147/NDT.S434130
DO - 10.2147/NDT.S434130
M3 - Article
C2 - 38155994
SN - 1176-6328
VL - 19
SP - 2817
EP - 2831
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
ER -