King's College London

Research portal

Treating Insulin Resistance with Intermittent Personalized Nutrition to Sustain Metabolic Health and Functioning Immune System for Risk Reduction of Viral Diseases Especially COVID-19 and Long-COVID

Research output: Contribution to journalArticlepeer-review

Markus Rohner, Peter E.H. Schwarz, Stefan R. Bornstein

Original languageEnglish
Pages (from-to)567-570
Number of pages4
JournalHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Issue number8
Published1 Aug 2022

Bibliographical note

Publisher Copyright: © 2022. Thieme. All rights reserved.

King's Authors


The Covid-19 pandemic has provided new and strong evidence for poor outcomes of viral infection in patients with poor metabolic health. Insulin resistance is at the root of many metabolic conditions and a key driver of their progression as it promotes ineffectual inflammation whilst impairing immune functions. In a vicious circle, insulin resistance facilitates SARS-CoV-2 infection, whilst infection drives insulin resistance. We discuss the underlying mechanisms and explore ways to improve metabolic health and prevent insulin resistance through early detection and targeted nutritional interventions. With proven efficacy in prediabetes, type 2 diabetes, and their cardiovascular and organ complications, as much as non-alcoholic liver disease, we argue to extend such approaches to ensure resilience to the current pandemic and viral challenges beyond.

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454