Treatment of neonatal abstinence syndrome

K Johnson; C Gerada; A Greenough

Treatment of neonatal abstinence syndrome

K Johnson, C Gerada, A Greenough

Research output: Contribution to journal › Literature review › peer-review

72 Citations (Scopus)

Abstract

Neonatal abstinence syndrome (NAS) is suffered by infants withdrawing from substances on which they have become physically dependent after in utero exposure. They may require prolonged treatment and spend weeks or even months in hospital. A wide range of drugs have been used to treat NAS. The efficacy of few, however, have been adequately investigated. Evidence suggests that opioids are the most appropriate, at least in infants exposed to diamorphine or methadone. In all "head to head" trials, diazepam has been shown to be ineffective. Morphine and methadone are currently the most commonly prescribed opioids to treat NAS, but randomised trials have not been undertaken to determine which is the more beneficial. Many infants with NAS have been exposed to multiple substances in utero. Further research is required into whether a single opiate or a multiple drug regimen is the best option for such patients.

Original language	English
Pages (from-to)	2 - 5
Number of pages	4
Journal	Archives of Disease in Childhood
Volume	88
Issue number	1
Publication status	Published - Jan 2003

Cite this

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author = "K Johnson and C Gerada and A Greenough",

year = "2003",

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language = "English",

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T1 - Treatment of neonatal abstinence syndrome

AU - Johnson, K

AU - Gerada, C

AU - Greenough, A

PY - 2003/1

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AB - Neonatal abstinence syndrome (NAS) is suffered by infants withdrawing from substances on which they have become physically dependent after in utero exposure. They may require prolonged treatment and spend weeks or even months in hospital. A wide range of drugs have been used to treat NAS. The efficacy of few, however, have been adequately investigated. Evidence suggests that opioids are the most appropriate, at least in infants exposed to diamorphine or methadone. In all "head to head" trials, diazepam has been shown to be ineffective. Morphine and methadone are currently the most commonly prescribed opioids to treat NAS, but randomised trials have not been undertaken to determine which is the more beneficial. Many infants with NAS have been exposed to multiple substances in utero. Further research is required into whether a single opiate or a multiple drug regimen is the best option for such patients.

M3 - Literature review

SN - 1468-2044

VL - 88

SP - 2

EP - 5

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

IS - 1

ER -

Treatment of neonatal abstinence syndrome

Abstract

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