Treatment of Pregnancy Complications in Antiphospholipid Syndrome

TY - CHAP

T1 - Treatment of Pregnancy Complications in Antiphospholipid Syndrome

AU - Nassar, Anwar

AU - Uthman, Imad

AU - Eid, Joe

AU - Khamashta, Munther

PY - 2016

Y1 - 2016

N2 - Antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis and pregnancy complications that include recurrent early pregnancy loss and late adverse pregnancy outcomes such as foetal death, severe preeclampsia, placental insufficiency, and foetal growth restriction. The pathogenic mechanisms that lead to injury in vivo are not clearly understood, and evidence-based management of ongoing pregnancies in women with APS and late pregnancy complications is difficult to provide due to the lack of randomized clinical trials for this particular group of women. In this chapter, we outline some of the proposed mechanisms by which antiphospholipid antibodies can cause and may perpetuate late complications of pregnancy. The identification of new mechanisms holds promise for new, more effective, and safer treatments. In addition, we focus on available therapeutic options for pregnant women with APS and late adverse pregnancy outcomes.

AB - Antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis and pregnancy complications that include recurrent early pregnancy loss and late adverse pregnancy outcomes such as foetal death, severe preeclampsia, placental insufficiency, and foetal growth restriction. The pathogenic mechanisms that lead to injury in vivo are not clearly understood, and evidence-based management of ongoing pregnancies in women with APS and late pregnancy complications is difficult to provide due to the lack of randomized clinical trials for this particular group of women. In this chapter, we outline some of the proposed mechanisms by which antiphospholipid antibodies can cause and may perpetuate late complications of pregnancy. The identification of new mechanisms holds promise for new, more effective, and safer treatments. In addition, we focus on available therapeutic options for pregnant women with APS and late adverse pregnancy outcomes.

KW - antiphospholipid antibodies

KW - Antiphospholipid syndrome

KW - foetal death

KW - preeclampsia

KW - pregnancy complications

UR - http://www.scopus.com/inward/record.url?scp=85016929449&partnerID=8YFLogxK

U2 - 10.1016/B978-0-444-63655-3.00018-1

DO - 10.1016/B978-0-444-63655-3.00018-1

M3 - Chapter

VL - 12

T3 - Handbook of Systemic Autoimmune Diseases

SP - 257

EP - 279

BT - Handbook of Systemic Autoimmune Diseases

PB - Elsevier Science Ltd

ER -