TY - JOUR
T1 - Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccine antibody prevalence in a multi-ethnic inner-city antenatal population
T2 - A cross-sectional surveillance study
AU - Andreeva, Daria
AU - Gill, Carolyn
AU - Brockbank, Anna
AU - Hejmej, Joanna
AU - Conti-Ramsden, Fran
AU - Doores, Katie J
AU - Seed, Paul T
AU - Poston, Lucilla
AU - eLIXIR Partnership
AU - Absoud, Michael
N1 - Funding Information:
This work was supported by eLIXIR Partnership developed by an MRC Partnership Grant (MR/P003060/1). The eLIXIR platform is also part‐supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King's College London. The eLIXIR research tissue bank was supported in part by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. Paul T Seed and Lucilla Poston are partly funded by Tommy's (Registered charity no. 1060508) and by ARC South London (NIHR).
Publisher Copyright:
© 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
PY - 2023/8
Y1 - 2023/8
N2 - Objective: To determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in pregnancy in an inner-city setting and assess associations with demographic factors and vaccination timing. Design: Repeated cross-sectional surveillance study. Setting: London maternity centre. Sample: A total of 906 pregnant women attending nuchal scans, July 2020–January 2022. Methods: Blood samples were tested for IgG antibodies against SARS-CoV-2 nucleocapsid (N) and spike (S) proteins. Self-reported vaccination status and coronavirus disease 2019 (COVID-19) infection were recorded. Multivariable regression models determined demographic factors associated with seroprevalence and antibody titres. Main outcome measures: Immunoglobulin G N- and S-protein antibody titres. Results: Of the 960 women, 196 (20.4%) were SARS-CoV-2 seropositive from previous infection. Of these, 70 (35.7%) self-reported previous infection. Among unvaccinated women, women of black ethnic backgrounds were most likely to be SARS-CoV-2 seropositive (versus white adjusted risk ratio [aRR] 1.88, 95% CI 1.35–2.61, p < 0.001). Women from black and mixed ethnic backgrounds were least likely to have a history of vaccination with seropositivity to S-protein (versus white aRR 0.58, 95% CI 0.40–0.84, p = 0.004; aRR 0.56, 95% CI 0.34–0.92, p = 0.021, respectively). Double vaccinated, previously infected women had higher IgG S-protein antibody titres than unvaccinated, previously infected women (mean difference 4.76 fold-change, 95% CI 2.65–6.86, p < 0.001). Vaccination timing before versus during pregnancy did not affect IgG S-antibody titres (mean difference −0.28 fold-change, 95% CI −2.61 to 2.04, p = 0.785). Conclusions: This cross-sectional study demonstrates high rates of asymptomatic SARS-CoV-2 infection with women of black ethnic backgrounds having higher infection risk and lower vaccine uptake. SARS-CoV-2 antibody titres were highest among double-vaccinated, infected women.
AB - Objective: To determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in pregnancy in an inner-city setting and assess associations with demographic factors and vaccination timing. Design: Repeated cross-sectional surveillance study. Setting: London maternity centre. Sample: A total of 906 pregnant women attending nuchal scans, July 2020–January 2022. Methods: Blood samples were tested for IgG antibodies against SARS-CoV-2 nucleocapsid (N) and spike (S) proteins. Self-reported vaccination status and coronavirus disease 2019 (COVID-19) infection were recorded. Multivariable regression models determined demographic factors associated with seroprevalence and antibody titres. Main outcome measures: Immunoglobulin G N- and S-protein antibody titres. Results: Of the 960 women, 196 (20.4%) were SARS-CoV-2 seropositive from previous infection. Of these, 70 (35.7%) self-reported previous infection. Among unvaccinated women, women of black ethnic backgrounds were most likely to be SARS-CoV-2 seropositive (versus white adjusted risk ratio [aRR] 1.88, 95% CI 1.35–2.61, p < 0.001). Women from black and mixed ethnic backgrounds were least likely to have a history of vaccination with seropositivity to S-protein (versus white aRR 0.58, 95% CI 0.40–0.84, p = 0.004; aRR 0.56, 95% CI 0.34–0.92, p = 0.021, respectively). Double vaccinated, previously infected women had higher IgG S-protein antibody titres than unvaccinated, previously infected women (mean difference 4.76 fold-change, 95% CI 2.65–6.86, p < 0.001). Vaccination timing before versus during pregnancy did not affect IgG S-antibody titres (mean difference −0.28 fold-change, 95% CI −2.61 to 2.04, p = 0.785). Conclusions: This cross-sectional study demonstrates high rates of asymptomatic SARS-CoV-2 infection with women of black ethnic backgrounds having higher infection risk and lower vaccine uptake. SARS-CoV-2 antibody titres were highest among double-vaccinated, infected women.
KW - early pregnancy
KW - infectious disease
KW - virology
KW - maternity services
KW - medical disorders in pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85157987896&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.17508
DO - 10.1111/1471-0528.17508
M3 - Article
C2 - 37113111
SN - 1470-0328
VL - 130
SP - 1135
EP - 1144
JO - BJOG
JF - BJOG
IS - 9
ER -
