Abstract
Background and aims: Functional post-stroke outcomes have improved with advances in acute treatment over recent decades, but the effects on mental health are unclear. We aimed to examine long-term trends in prevalence of post-stroke depression during 1995-2018.
Methods: The study was based on South London Stroke Register (SLSR) in 1995-2018. Prior-stroke depression diagnoses were collected from GP/hospital record, with 3-month and annual follow-up depressive symptoms assessed using the Hospital Anxiety and Depression Scale. The 24-year analysis was split into six four-year periods for trend smoothing. Logistic regressions were selected to estimate changes for six-period depression comparing 2015-2018 with 1995-1998, repeated for periodic changes in age, gender, ethnicity and prior-stroke depression subgroups, and to estimate variations for the four factors in the trend adjusted by time.
Results: Of the 6687 patients registered in SLSR, 81.16 % were aged 56 and over, 48.59% were female, 65.59% were White, and 8.54% had pre-stroke depression. The overall trend increased non-significantly comparing 2015-2018 and 1995-1998 (OR 1.20, 95%CI 0.94-1.53). Trends were similar across different age, gender and pre-stroke depression groups (OR >1.14, p >0.1) except for different ethnicity, but none of them were significant. Across all cohorts the prevalence was higher for female (OR 1.11, 95%CI 1.02-1.21), non-white patients (e.g., Black: OR 1.14, 95%CI 1.04-1.26) and patients with pre-stroke depression (OR 1.66, 95%CI 1.45-1.90).
Conclusions: The was a slight and non-significant increase in the prevalence of post-stroke depression over the 24 years, despite concurrent improvement in stroke treatment. This was similar across all population groups.
Methods: The study was based on South London Stroke Register (SLSR) in 1995-2018. Prior-stroke depression diagnoses were collected from GP/hospital record, with 3-month and annual follow-up depressive symptoms assessed using the Hospital Anxiety and Depression Scale. The 24-year analysis was split into six four-year periods for trend smoothing. Logistic regressions were selected to estimate changes for six-period depression comparing 2015-2018 with 1995-1998, repeated for periodic changes in age, gender, ethnicity and prior-stroke depression subgroups, and to estimate variations for the four factors in the trend adjusted by time.
Results: Of the 6687 patients registered in SLSR, 81.16 % were aged 56 and over, 48.59% were female, 65.59% were White, and 8.54% had pre-stroke depression. The overall trend increased non-significantly comparing 2015-2018 and 1995-1998 (OR 1.20, 95%CI 0.94-1.53). Trends were similar across different age, gender and pre-stroke depression groups (OR >1.14, p >0.1) except for different ethnicity, but none of them were significant. Across all cohorts the prevalence was higher for female (OR 1.11, 95%CI 1.02-1.21), non-white patients (e.g., Black: OR 1.14, 95%CI 1.04-1.26) and patients with pre-stroke depression (OR 1.66, 95%CI 1.45-1.90).
Conclusions: The was a slight and non-significant increase in the prevalence of post-stroke depression over the 24 years, despite concurrent improvement in stroke treatment. This was similar across all population groups.
| Original language | English |
|---|---|
| Article number | O135/1408 |
| Pages (from-to) | 82-82 |
| Journal | European Stroke Journal |
| Volume | 8 |
| Issue number | 2_suppl |
| DOIs | |
| Publication status | Published - 24 May 2023 |
