TRP channels in the sensation of heat

TY - CHAP

T1 - TRP channels in the sensation of heat

AU - Tan, Chun Hsiang

AU - McNaughton, Peter A.

PY - 2015/8/24

Y1 - 2015/8/24

N2 - Animals must sense temperature in the external environment in order to find ambient temperatures appropriate for different activities, such as hunting or sleeping, and to avoid even brief exposure to damaging extremes of temperature. They must also sense their internal bodily temperature in order to regulate it. Some members of the TRP channel family are activated by thermal stimuli, and are consequently named the thermoTRPs; thermally sensitive ion channels are also found in the potassium and chloride channel families. When thermoTRP channels are expressed in a sensory neuron, channel opening in response to heat leads to depolarization and generation of action potentials. It is still an open question which channels are important for sensation of thermal stimuli in the external environment, and channels involved in the sensation of internal bodily temperature for the purposes of thermoregulation are even less understood. In this chapter we review the properties of thermosensitive ion channels and their roles in thermosensation and thermoregulation, with an emphasis on TRP channels.

AB - Animals must sense temperature in the external environment in order to find ambient temperatures appropriate for different activities, such as hunting or sleeping, and to avoid even brief exposure to damaging extremes of temperature. They must also sense their internal bodily temperature in order to regulate it. Some members of the TRP channel family are activated by thermal stimuli, and are consequently named the thermoTRPs; thermally sensitive ion channels are also found in the potassium and chloride channel families. When thermoTRP channels are expressed in a sensory neuron, channel opening in response to heat leads to depolarization and generation of action potentials. It is still an open question which channels are important for sensation of thermal stimuli in the external environment, and channels involved in the sensation of internal bodily temperature for the purposes of thermoregulation are even less understood. In this chapter we review the properties of thermosensitive ion channels and their roles in thermosensation and thermoregulation, with an emphasis on TRP channels.

KW - Heat transduction

KW - Thermoregulation

KW - Thermosensation

KW - TRP channels

UR - http://www.scopus.com/inward/record.url?scp=84955413742&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-18705-1_8

DO - 10.1007/978-3-319-18705-1_8

M3 - Chapter

AN - SCOPUS:84955413742

SN - 9783319187051

SN - 9783319187044

SP - 165

EP - 183

BT - TRP Channels in Sensory Transduction

PB - Springer International Publishing Switzerland

ER -