Truncated apoE forms tangle-like structures in a neuronal cell line

M C Ljungberg, R Dayanandan, A Asuni, T H Rupniak, B H Anderton, S Lovestone

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Apolipoprotein E is the predominant brain lipoprotein and polymorphic variation in the APOE gene the major genetic susceptibly factor for late onset Alzheimer's disease (AD). Recently it was reported that carboxyl-truncated ApoE fragments induce tangle-like structures in neurons. We confirm the finding: in mouse neuroblastoma cells truncated apoE fragments lacking the carboxy-terminus induce structures that have the appearance of neurofibrillary tangles. However these tangles are not induced in non-neuronal cells even in the presence of co-expressed neurofilaments or tau. Further understanding of the basis of this cell specificity might add to understanding of the cell specificity of tangles in AD. NeuroReport 13:867-870 (C) 2002 Lippincott Williams Wilkins.
Original languageEnglish
Pages (from-to)867 - 870
Number of pages4
JournalNeuroreport
Volume13
Issue number6
DOIs
Publication statusPublished - 7 May 2002

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