Abstract
Background: Magnetic resonance elastography (MRE) is an emerging imaging technique that affords non-invasive quantitative assessment and visualization of tissue mechanical properties in vivo.
Methods: In this study, MRE was used to quantify (kPa) the absolute value of the complex shear modulus |G*|, elasticity G(d) and viscosity G(l) of SW620 human colorectal cancer xenografts before and 24 h after treatment with either 200 mgkg(-1) of the vascular disrupting agent ZD6126 (N-acetylcolchinol-O-phosphate) or vehicle control, and the data were compared with changes in water diffusivity measured by diffusion-weighted magnetic resonance imaging.
Results: A heterogeneous distribution of |G*|, Gd and Gl was observed pre-treatment with an intertumoral coefficient of variation of 13% for |G*|. There were no significant changes in the vehicle-treated cohort. In contrast, ZD6126 induced a significant decrease in the tumour-averaged |G*| (Po0.01), G(d) (P
Conclusions: These data demonstrate that MRE can provide early imaging biomarkers for treatment-induced tumour necrosis.
| Original language | English |
|---|---|
| Pages (from-to) | 1727-1732 |
| Number of pages | 6 |
| Journal | BJC: British Journal of Cancer |
| Volume | 110 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2 Apr 2014 |
Keywords
- tumour viscoelasticity
- magnetic resonance elastography
- vascular targeting agents
- response biomarker
- ONCOLOGY DRUG DEVELOPMENT
- MR ELASTOGRAPHY
- TARGETING AGENT
- ANTITUMOR-ACTIVITY
- BREAST
- BIOMARKERS
- GUIDELINES
- THERAPY
