Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography

J. Li*, Y. Jamin, J. K. R. Boult, C. Cummings, J. C. Waterton, J. Ulloa, R. Sinkus, J. C. Bamber, S. P. Robinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Background: Magnetic resonance elastography (MRE) is an emerging imaging technique that affords non-invasive quantitative assessment and visualization of tissue mechanical properties in vivo.

Methods: In this study, MRE was used to quantify (kPa) the absolute value of the complex shear modulus |G*|, elasticity G(d) and viscosity G(l) of SW620 human colorectal cancer xenografts before and 24 h after treatment with either 200 mgkg(-1) of the vascular disrupting agent ZD6126 (N-acetylcolchinol-O-phosphate) or vehicle control, and the data were compared with changes in water diffusivity measured by diffusion-weighted magnetic resonance imaging.

Results: A heterogeneous distribution of |G*|, Gd and Gl was observed pre-treatment with an intertumoral coefficient of variation of 13% for |G*|. There were no significant changes in the vehicle-treated cohort. In contrast, ZD6126 induced a significant decrease in the tumour-averaged |G*| (Po0.01), G(d) (P

Conclusions: These data demonstrate that MRE can provide early imaging biomarkers for treatment-induced tumour necrosis.

Original languageEnglish
Pages (from-to)1727-1732
Number of pages6
JournalBJC: British Journal of Cancer
Volume110
Issue number7
DOIs
Publication statusPublished - 2 Apr 2014

Keywords

  • tumour viscoelasticity
  • magnetic resonance elastography
  • vascular targeting agents
  • response biomarker
  • ONCOLOGY DRUG DEVELOPMENT
  • MR ELASTOGRAPHY
  • TARGETING AGENT
  • ANTITUMOR-ACTIVITY
  • BREAST
  • BIOMARKERS
  • GUIDELINES
  • THERAPY

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