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Tuning neural circuits by turning the interneuron knob

Research output: Contribution to journalArticle

Nathalie Dehorter, Nicolás Marichal, Oscar Marín, Benedikt Berninger

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalCURRENT OPINION IN NEUROBIOLOGY
Volume42
Early online date11 Jan 2017
DOIs
Publication statusPublished - 1 Feb 2017

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Abstract

Interneurons play a critical role in sculpting neuronal circuit activity and their dysfunction can result in neurological and neuropsychiatric disorders. To temporally structure and balance neuronal activity in the adult brain interneurons display a remarkable degree of subclass-specific plasticity, of which the underlying molecular mechanisms have recently begun to be elucidated. Grafting new interneurons to pre-existing neuronal networks allows for amelioration of circuit dysfunction in rodent models of neurological disease and can reopen critical windows for circuit plasticity. The crucial contribution of specific classes of interneurons to circuit homeostasis and plasticity in health and disease underscores their generation as an important objective for emerging strategies of lineage reprogramming in vivo.

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