TURNER SYNDROME: NEUROIMAGING FINDINGS: STRUCTURAL AND FUNCTIONAL

TY - JOUR

T1 - TURNER SYNDROME: NEUROIMAGING FINDINGS: STRUCTURAL AND FUNCTIONAL

AU - Mullaney, Ronan

AU - Murphy, Declan

PY - 2009

Y1 - 2009

N2 - Neuroimaging studies of Turner syndrome can advance our understanding of the X chromosome in brain development, and the modulatory influence of endocrine factors. There is increasing evidence from neuroimaging studies that TX individuals have significant differences in the anatomy, function, and metabolism of a number of brain regions; including the parietal lobe; cerebellum, amygdala, hippocampus; and basal ganglia; and perhaps differences in "connectivity" between frontal and parieto-occipital regions. Finally, there is preliminary evidence that genomic imprinting, sex hormones and growth hormone have significant modulatory effects on brain maturation in TS. (C) 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009:15:279-283.

AB - Neuroimaging studies of Turner syndrome can advance our understanding of the X chromosome in brain development, and the modulatory influence of endocrine factors. There is increasing evidence from neuroimaging studies that TX individuals have significant differences in the anatomy, function, and metabolism of a number of brain regions; including the parietal lobe; cerebellum, amygdala, hippocampus; and basal ganglia; and perhaps differences in "connectivity" between frontal and parieto-occipital regions. Finally, there is preliminary evidence that genomic imprinting, sex hormones and growth hormone have significant modulatory effects on brain maturation in TS. (C) 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009:15:279-283.

U2 - 10.1002/ddrr.87

DO - 10.1002/ddrr.87

M3 - Literature review

VL - 15

SP - 279

EP - 283

JO - Developmental Disabilities Research Reviews

JF - Developmental Disabilities Research Reviews

IS - 4

ER -