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TURNER SYNDROME: NEUROIMAGING FINDINGS: STRUCTURAL AND FUNCTIONAL

Research output: Contribution to journalLiterature review

Ronan Mullaney, Declan Murphy

Original languageEnglish
Pages (from-to)279 - 283
Number of pages5
JournalDevelopmental Disabilities Research Reviews
Volume15
Issue number4
DOIs
Publication statusPublished - 2009

King's Authors

Abstract

Neuroimaging studies of Turner syndrome can advance our understanding of the X chromosome in brain development, and the modulatory influence of endocrine factors. There is increasing evidence from neuroimaging studies that TX individuals have significant differences in the anatomy, function, and metabolism of a number of brain regions; including the parietal lobe; cerebellum, amygdala, hippocampus; and basal ganglia; and perhaps differences in "connectivity" between frontal and parieto-occipital regions. Finally, there is preliminary evidence that genomic imprinting, sex hormones and growth hormone have significant modulatory effects on brain maturation in TS. (C) 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009:15:279-283.

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