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TwinsUK: The UK Adult Twin Registry Update 

Research output: Contribution to journalArticle

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TwinsUK: The UK Adult Twin Registry Update . / Steves, Claire Joanne; Menni, Cristina; Spector, Timothy David; Small, Kerrin Shannon; Christofidou, Paraskevi; Williams, Frances Mary Kingsley; Hammond, Christopher John; Hart, Deborah Jane; Bowyer, Ruth Catherine Emma.

In: TWIN RESEARCH AND HUMAN GENETICS, 26.06.2019.

Research output: Contribution to journalArticle

Harvard

Steves, CJ, Menni, C, Spector, TD, Small, KS, Christofidou, P, Williams, FMK, Hammond, CJ, Hart, DJ & Bowyer, RCE 2019, 'TwinsUK: The UK Adult Twin Registry Update ', TWIN RESEARCH AND HUMAN GENETICS.

APA

Steves, C. J., Menni, C., Spector, T. D., Small, K. S., Christofidou, P., Williams, F. M. K., ... Bowyer, R. C. E. (Accepted/In press). TwinsUK: The UK Adult Twin Registry Update . TWIN RESEARCH AND HUMAN GENETICS.

Vancouver

Steves CJ, Menni C, Spector TD, Small KS, Christofidou P, Williams FMK et al. TwinsUK: The UK Adult Twin Registry Update . TWIN RESEARCH AND HUMAN GENETICS. 2019 Jun 26.

Author

Steves, Claire Joanne ; Menni, Cristina ; Spector, Timothy David ; Small, Kerrin Shannon ; Christofidou, Paraskevi ; Williams, Frances Mary Kingsley ; Hammond, Christopher John ; Hart, Deborah Jane ; Bowyer, Ruth Catherine Emma. / TwinsUK: The UK Adult Twin Registry Update . In: TWIN RESEARCH AND HUMAN GENETICS. 2019.

Bibtex Download

@article{ef68ae81e69c4f76b50e235b1a8f5e2c,
title = "TwinsUK: The UK Adult Twin Registry Update ",
abstract = "TwinsUK is the largest cohort of community dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets), it is predominantly female (82{\%}) and middle aged (mean age 59). In addition, over 1,800 parents and siblings of twins are registered volunteers. During the last 25 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8,500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioural, dietary and socio-economic cohort characterisation; it provides a multidisciplinary platform for the study of complex disease during the adult life-course, including the process of healthy ageing. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genome-wide scans of single nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community – interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK. ",
author = "Steves, {Claire Joanne} and Cristina Menni and Spector, {Timothy David} and Small, {Kerrin Shannon} and Paraskevi Christofidou and Williams, {Frances Mary Kingsley} and Hammond, {Christopher John} and Hart, {Deborah Jane} and Bowyer, {Ruth Catherine Emma}",
year = "2019",
month = "6",
day = "26",
language = "English",
journal = "TWIN RESEARCH AND HUMAN GENETICS",
issn = "1832-4274",
publisher = "Cambridge University Press",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - TwinsUK: The UK Adult Twin Registry Update 

AU - Steves, Claire Joanne

AU - Menni, Cristina

AU - Spector, Timothy David

AU - Small, Kerrin Shannon

AU - Christofidou, Paraskevi

AU - Williams, Frances Mary Kingsley

AU - Hammond, Christopher John

AU - Hart, Deborah Jane

AU - Bowyer, Ruth Catherine Emma

PY - 2019/6/26

Y1 - 2019/6/26

N2 - TwinsUK is the largest cohort of community dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets), it is predominantly female (82%) and middle aged (mean age 59). In addition, over 1,800 parents and siblings of twins are registered volunteers. During the last 25 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8,500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioural, dietary and socio-economic cohort characterisation; it provides a multidisciplinary platform for the study of complex disease during the adult life-course, including the process of healthy ageing. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genome-wide scans of single nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community – interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK. 

AB - TwinsUK is the largest cohort of community dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets), it is predominantly female (82%) and middle aged (mean age 59). In addition, over 1,800 parents and siblings of twins are registered volunteers. During the last 25 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8,500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioural, dietary and socio-economic cohort characterisation; it provides a multidisciplinary platform for the study of complex disease during the adult life-course, including the process of healthy ageing. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genome-wide scans of single nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community – interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK. 

M3 - Article

JO - TWIN RESEARCH AND HUMAN GENETICS

JF - TWIN RESEARCH AND HUMAN GENETICS

SN - 1832-4274

ER -

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