Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population

Rosa María Salinas; Marcia Hiriart; Isaac Acosta; Ana Luisa Sosa; Martin J Prince

doi:10.1016/j.jdiacomp.2016.06.005

Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population

Rosa María Salinas, Marcia Hiriart, Isaac Acosta, Ana Luisa Sosa, Martin J Prince

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Abstract

INTRODUCTION: Type 2 diabetes mellitus (T2DM) and dementia increase with age. Different studies have explored their association, but the possible relationship between them is still unclear.

METHODS: This is an analysis of the 10/66 Dementia Research Group (DRG) Mexico database; the sample comprised 1193 subjects ≥65 years old followed-up for three years. We calculated the incidence of dementia in subjects with diabetes using three models of analysis.

RESULTS: T2DM patients have nearly twice the risk of developing dementia (RR 1.9; 95% CI 1.3-2.6) after three years of follow-up. The incidence of dementia is higher in subjects with undiagnosed diabetes. Higher serum glucose levels have a stronger association with dementia.

CONCLUSIONS: It is important to implement early evaluation and monitoring cognitive performance in elders with diabetes to identify minor cognitive impairment and undertake timely interventions to prevent or delay the onset of dementia.

Original language	English
Pages (from-to)	1234–1239
Number of pages	6
Journal	Journal of Diabetes and Its Complications
Volume	30
Issue number	7
Early online date	9 Jun 2016
DOIs	https://doi.org/10.1016/j.jdiacomp.2016.06.005
Publication status	Published - 1 Sept 2016

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Cite this

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title = "Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population",

abstract = "INTRODUCTION: Type 2 diabetes mellitus (T2DM) and dementia increase with age. Different studies have explored their association, but the possible relationship between them is still unclear.METHODS: This is an analysis of the 10/66 Dementia Research Group (DRG) Mexico database; the sample comprised 1193 subjects ≥65 years old followed-up for three years. We calculated the incidence of dementia in subjects with diabetes using three models of analysis.RESULTS: T2DM patients have nearly twice the risk of developing dementia (RR 1.9; 95% CI 1.3-2.6) after three years of follow-up. The incidence of dementia is higher in subjects with undiagnosed diabetes. Higher serum glucose levels have a stronger association with dementia.CONCLUSIONS: It is important to implement early evaluation and monitoring cognitive performance in elders with diabetes to identify minor cognitive impairment and undertake timely interventions to prevent or delay the onset of dementia.",

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doi = "10.1016/j.jdiacomp.2016.06.005",

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T1 - Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population

AU - Salinas, Rosa María

AU - Hiriart, Marcia

AU - Acosta, Isaac

AU - Sosa, Ana Luisa

AU - Prince, Martin J

PY - 2016/9/1

Y1 - 2016/9/1

N2 - INTRODUCTION: Type 2 diabetes mellitus (T2DM) and dementia increase with age. Different studies have explored their association, but the possible relationship between them is still unclear.METHODS: This is an analysis of the 10/66 Dementia Research Group (DRG) Mexico database; the sample comprised 1193 subjects ≥65 years old followed-up for three years. We calculated the incidence of dementia in subjects with diabetes using three models of analysis.RESULTS: T2DM patients have nearly twice the risk of developing dementia (RR 1.9; 95% CI 1.3-2.6) after three years of follow-up. The incidence of dementia is higher in subjects with undiagnosed diabetes. Higher serum glucose levels have a stronger association with dementia.CONCLUSIONS: It is important to implement early evaluation and monitoring cognitive performance in elders with diabetes to identify minor cognitive impairment and undertake timely interventions to prevent or delay the onset of dementia.

AB - INTRODUCTION: Type 2 diabetes mellitus (T2DM) and dementia increase with age. Different studies have explored their association, but the possible relationship between them is still unclear.METHODS: This is an analysis of the 10/66 Dementia Research Group (DRG) Mexico database; the sample comprised 1193 subjects ≥65 years old followed-up for three years. We calculated the incidence of dementia in subjects with diabetes using three models of analysis.RESULTS: T2DM patients have nearly twice the risk of developing dementia (RR 1.9; 95% CI 1.3-2.6) after three years of follow-up. The incidence of dementia is higher in subjects with undiagnosed diabetes. Higher serum glucose levels have a stronger association with dementia.CONCLUSIONS: It is important to implement early evaluation and monitoring cognitive performance in elders with diabetes to identify minor cognitive impairment and undertake timely interventions to prevent or delay the onset of dementia.

U2 - 10.1016/j.jdiacomp.2016.06.005

DO - 10.1016/j.jdiacomp.2016.06.005

M3 - Article

C2 - 27344092

SN - 1056-8727

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EP - 1239

JO - Journal of Diabetes and Its Complications

JF - Journal of Diabetes and Its Complications

IS - 7

ER -

Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population

Abstract

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