Typical antipsychotic drugs - D-2 receptor occupancy and depressive symptoms in schizophrenia

R A Bressan; D C Costa; H M Jones; P J Ell; L S Pilowsky

Typical antipsychotic drugs - D-2 receptor occupancy and depressive symptoms in schizophrenia

R A Bressan, D C Costa, H M Jones, P J Ell, L S Pilowsky

King's College London

Research output: Contribution to journal › Conference paper

Abstract

We tested the hypothesis that the degree of striatal dopamine D-2 receptor blockade induced by typical antipsychotic treatment directly correlates with the presence and severity of depressive symptoms in schizophrenia. Clinical and [I-123]-IBZM Single photon emission tomography (SPET) scan data obtained from 18 typical antipsychotic treated schizophrenic patients was analysed to evaluate the relationship between striatal D, receptor occupancy and the depressive subscale of the Brief Psychiatric Rating Scale (BPRS-D). Striatal D-2 receptor occupancy by typical antipsychotic drugs was significantly positively correlated with BPRS-D scores (r = 0,52, p = 0.025). This study suggests that high striatal dopamine D-2 blockade by typical antipsychotic drugs may contribute to the emergence of depressive symptoms in typical antipsychotic treated schizophrenic patients. (C) 2002 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	31 - 36
Number of pages	6
Journal	Schizophrenia Research
Volume	56
Issue number	1-2
Publication status	Published - 2002
Event	55th Annual Meeting of the Society-of-Biological-Psychiatry - CHICAGO, ILLINOIS Duration: 1 Jan 2002 → …

Cite this

@article{d3ba42520d51406babda5fa837ed3335,

title = "Typical antipsychotic drugs - D-2 receptor occupancy and depressive symptoms in schizophrenia",

abstract = "We tested the hypothesis that the degree of striatal dopamine D-2 receptor blockade induced by typical antipsychotic treatment directly correlates with the presence and severity of depressive symptoms in schizophrenia. Clinical and [I-123]-IBZM Single photon emission tomography (SPET) scan data obtained from 18 typical antipsychotic treated schizophrenic patients was analysed to evaluate the relationship between striatal D, receptor occupancy and the depressive subscale of the Brief Psychiatric Rating Scale (BPRS-D). Striatal D-2 receptor occupancy by typical antipsychotic drugs was significantly positively correlated with BPRS-D scores (r = 0,52, p = 0.025). This study suggests that high striatal dopamine D-2 blockade by typical antipsychotic drugs may contribute to the emergence of depressive symptoms in typical antipsychotic treated schizophrenic patients. (C) 2002 Elsevier Science B.V. All rights reserved.",

author = "Bressan, {R A} and Costa, {D C} and Jones, {H M} and Ell, {P J} and Pilowsky, {L S}",

year = "2002",

language = "English",

volume = "56",

pages = "31 -- 36",

journal = "Schizophrenia Research",

issn = "1573-2509",

publisher = "Elsevier",

number = "1-2",

note = "55th Annual Meeting of the Society-of-Biological-Psychiatry ; Conference date: 01-01-2002",

}

TY - JOUR

T1 - Typical antipsychotic drugs - D-2 receptor occupancy and depressive symptoms in schizophrenia

AU - Bressan, R A

AU - Costa, D C

AU - Jones, H M

AU - Ell, P J

AU - Pilowsky, L S

PY - 2002

Y1 - 2002

N2 - We tested the hypothesis that the degree of striatal dopamine D-2 receptor blockade induced by typical antipsychotic treatment directly correlates with the presence and severity of depressive symptoms in schizophrenia. Clinical and [I-123]-IBZM Single photon emission tomography (SPET) scan data obtained from 18 typical antipsychotic treated schizophrenic patients was analysed to evaluate the relationship between striatal D, receptor occupancy and the depressive subscale of the Brief Psychiatric Rating Scale (BPRS-D). Striatal D-2 receptor occupancy by typical antipsychotic drugs was significantly positively correlated with BPRS-D scores (r = 0,52, p = 0.025). This study suggests that high striatal dopamine D-2 blockade by typical antipsychotic drugs may contribute to the emergence of depressive symptoms in typical antipsychotic treated schizophrenic patients. (C) 2002 Elsevier Science B.V. All rights reserved.

AB - We tested the hypothesis that the degree of striatal dopamine D-2 receptor blockade induced by typical antipsychotic treatment directly correlates with the presence and severity of depressive symptoms in schizophrenia. Clinical and [I-123]-IBZM Single photon emission tomography (SPET) scan data obtained from 18 typical antipsychotic treated schizophrenic patients was analysed to evaluate the relationship between striatal D, receptor occupancy and the depressive subscale of the Brief Psychiatric Rating Scale (BPRS-D). Striatal D-2 receptor occupancy by typical antipsychotic drugs was significantly positively correlated with BPRS-D scores (r = 0,52, p = 0.025). This study suggests that high striatal dopamine D-2 blockade by typical antipsychotic drugs may contribute to the emergence of depressive symptoms in typical antipsychotic treated schizophrenic patients. (C) 2002 Elsevier Science B.V. All rights reserved.

M3 - Conference paper

SN - 1573-2509

VL - 56

SP - 31

EP - 36

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-2

T2 - 55th Annual Meeting of the Society-of-Biological-Psychiatry

Y2 - 1 January 2002

ER -

Typical antipsychotic drugs - D-2 receptor occupancy and depressive symptoms in schizophrenia

Abstract

Fingerprint

Cite this