Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells

Jingqian Jiang; Varsha Kanabar; Beatriz Padilla; Francis Man; Simon C. Pitchford; Clive P. Page; Gerd K. Wagner

doi:10.1039/c5cc09289b

Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells

Jingqian Jiang, Varsha Kanabar, Beatriz Padilla, Francis Man, Simon C. Pitchford, Clive P. Page, Gerd K. Wagner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We report 5-substituted uridine derivatives as novel, uncharged inhibitors of β-1,4-galactosyltransferase and chemical tools for cellular applications. The new inhibitors reduce P-selectin glycoprotein 1 (PSGL-1) expression in human monocytes. Our results also provide novel insights into a unique mode of glycosyltransferase inhibition.

Original language	English
Pages (from-to)	3955-3958
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	52
Issue number	20
DOIs	https://doi.org/10.1039/c5cc09289b
Publication status	Published - 16 Feb 2016

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c5cc09289bFinal published version, 1.5 MBLicence: CC BY

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AU - Jiang, Jingqian

AU - Kanabar, Varsha

AU - Padilla, Beatriz

AU - Man, Francis

AU - Pitchford, Simon C.

AU - Page, Clive P.

AU - Wagner, Gerd K.

PY - 2016/2/16

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AB - We report 5-substituted uridine derivatives as novel, uncharged inhibitors of β-1,4-galactosyltransferase and chemical tools for cellular applications. The new inhibitors reduce P-selectin glycoprotein 1 (PSGL-1) expression in human monocytes. Our results also provide novel insights into a unique mode of glycosyltransferase inhibition.

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JO - Chemical communications (Cambridge, England)

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Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells

Abstract

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