Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
163 Downloads (Pure)

Abstract

We report 5-substituted uridine derivatives as novel, uncharged inhibitors of β-1,4-galactosyltransferase and chemical tools for cellular applications. The new inhibitors reduce P-selectin glycoprotein 1 (PSGL-1) expression in human monocytes. Our results also provide novel insights into a unique mode of glycosyltransferase inhibition.

Original languageEnglish
Pages (from-to)3955-3958
Number of pages4
JournalChemical communications (Cambridge, England)
Volume52
Issue number20
DOIs
Publication statusPublished - 16 Feb 2016

Fingerprint

Dive into the research topics of 'Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells'. Together they form a unique fingerprint.

Cite this