Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides

Silvia Anselmi; Nandini Aggarwal; Thomas S. Moody; Daniele Castagnolo

doi:10.1002/cbic.202000430

Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides

Silvia Anselmi, Nandini Aggarwal, Thomas S. Moody, Daniele Castagnolo^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Sulfoxides are a class of organic compounds that find wide application in medicinal and organic chemistry. Several biocatalytic approaches have been developed to synthesise enantioenriched sulfoxides, mainly by exploiting oxidative enzymes. Recently, the use of reductive enzymes such as Msr and Dms has emerged as a new, alternative method to obtain enantiopure sulfoxides from racemic mixtures. In parallel, novel oxidative approaches, employing nonclassical solvents such as ionic liquids (ILs) and deep eutectic solvents (DESs), have been developed as greener and more sustainable biocatalytic synthetic pathways. This minireview aims highlights the recent advances made in the biocatalytic synthesis of enantioenriched sulfoxides by employing such unconventional approaches.

Original language	English
Pages (from-to)	298-307
Number of pages	10
Journal	ChemBioChem
Volume	22
Issue number	2
Early online date	31 Jul 2020
DOIs	https://doi.org/10.1002/cbic.202000430
Publication status	Published - 15 Jan 2021

Keywords

biocatalysis
deep eutectics
ionic liquids
reductive enzymes
sulfoxides

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10.1002/cbic.202000430

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title = "Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides",

abstract = "Sulfoxides are a class of organic compounds that find wide application in medicinal and organic chemistry. Several biocatalytic approaches have been developed to synthesise enantioenriched sulfoxides, mainly by exploiting oxidative enzymes. Recently, the use of reductive enzymes such as Msr and Dms has emerged as a new, alternative method to obtain enantiopure sulfoxides from racemic mixtures. In parallel, novel oxidative approaches, employing nonclassical solvents such as ionic liquids (ILs) and deep eutectic solvents (DESs), have been developed as greener and more sustainable biocatalytic synthetic pathways. This minireview aims highlights the recent advances made in the biocatalytic synthesis of enantioenriched sulfoxides by employing such unconventional approaches.",

keywords = "biocatalysis, deep eutectics, ionic liquids, reductive enzymes, sulfoxides",

author = "Silvia Anselmi and Nandini Aggarwal and Moody, {Thomas S.} and Daniele Castagnolo",

note = "Funding Information: We gratefully acknowledge BBSRC LIDo (BB/M009513/1) for PhD Studentship to S.A. Publisher Copyright: {\textcopyright} 2020 The Authors. Published by Wiley-VCH GmbH",

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doi = "10.1002/cbic.202000430",

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AU - Moody, Thomas S.

AU - Castagnolo, Daniele

PY - 2021/1/15

Y1 - 2021/1/15

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Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides

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