Understanding and mitigating associations between childhood neighborhood deprivation and adolescent mental health in two UK birth cohorts

Rachel Latham; Louise Arseneault; George Ploubidis; Jayati Das-Munshi; Dario Moreno-Agostino; Ioannis Bakolis; Flora Blangis; Helen L. Fisher

doi:10.1017/S0954579425000203

Understanding and mitigating associations between childhood neighborhood deprivation and adolescent mental health in two UK birth cohorts

Rachel Latham, Louise Arseneault, George Ploubidis, Jayati Das-Munshi, Dario Moreno-Agostino, Ioannis Bakolis, Flora Blangis, Helen L. Fisher

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Abstract

This study investigated associations between childhood neighborhood deprivation and adolescent mental health difficulties, and potential protective factors. Data were utilized from the Millennium Cohort Study (MCS) (born in 2000-2002; N = 5,422; 52% female) and the Environmental Risk (E-Risk) Longitudinal Twin Study (born in 1994-1995; N = 1,920; 53% female). Childhood neighborhood deprivation was measured using the Index of Multiple Deprivation between age 9 months and 14 years (MCS) and at age 12 (E-Risk). Adolescent mental health was assessed using the Strengths and Difficulties Questionnaire at age 17 (MCS) and the Diagnostic Interview Schedule conducted at age 18 with symptoms loading onto general psychopathology, internalizing and externalizing factors (E-Risk). Cross-classified models showed high levels of neighborhood deprivation in childhood were associated with more total problems (estimate = 0.46, 95% CI = 0.04-0.88) and internalizing difficulties (estimate = 0.32, 95% CI = 0.06-0.59) in adolescence within MCS. Being male, having higher self-esteem, greater social support, and a more positive parent-child relationship were associated with fewer total problems (estimates = -0.09 - 1.87) and internalizing difficulties (estimates = -0.03 - 1.88) at age 17 in the full sample regardless of neighborhood deprivation exposure. However, interactions revealed that higher self-esteem was especially beneficial for children exposed to high neighborhood deprivation (estimate = -0.35, 95% CI = -0.43 - 0.27). No significant associations between childhood neighborhood deprivation and adolescent mental health symptoms were found in E-Risk. Interventions focused on improving self-esteem, social support, and parenting may help promote better adolescent mental health in the general population. Those living in the most deprived areas may benefit most from increased self-esteem.

Original language	English
Number of pages	15
Journal	Development and Psychopathology
Early online date	7 Apr 2025
DOIs	https://doi.org/10.1017/S0954579425000203
Publication status	E-pub ahead of print - 7 Apr 2025

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Understanding and Mitigating_LATHAM_Accepted05March2025 GREEN AAM (CC-BY)Accepted author manuscript, 602 KBLicence: CC BY
Understanding and Mitigating_LATHAM_Publishedonline07April2025_GOLD VoR (CC-BY)Final published version, 435 KBLicence: CC BY

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Latham, R., Arseneault, L., Ploubidis, G., Das-Munshi, J., Moreno-Agostino, D., Bakolis, I., Blangis, F., & Fisher, H. L. (2025). Understanding and mitigating associations between childhood neighborhood deprivation and adolescent mental health in two UK birth cohorts. Development and Psychopathology. Advance online publication. https://doi.org/10.1017/S0954579425000203

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title = "Understanding and mitigating associations between childhood neighborhood deprivation and adolescent mental health in two UK birth cohorts",

abstract = "This study investigated associations between childhood neighborhood deprivation and adolescent mental health difficulties, and potential protective factors. Data were utilized from the Millennium Cohort Study (MCS) (born in 2000-2002; N = 5,422; 52% female) and the Environmental Risk (E-Risk) Longitudinal Twin Study (born in 1994-1995; N = 1,920; 53% female). Childhood neighborhood deprivation was measured using the Index of Multiple Deprivation between age 9 months and 14 years (MCS) and at age 12 (E-Risk). Adolescent mental health was assessed using the Strengths and Difficulties Questionnaire at age 17 (MCS) and the Diagnostic Interview Schedule conducted at age 18 with symptoms loading onto general psychopathology, internalizing and externalizing factors (E-Risk). Cross-classified models showed high levels of neighborhood deprivation in childhood were associated with more total problems (estimate = 0.46, 95% CI = 0.04-0.88) and internalizing difficulties (estimate = 0.32, 95% CI = 0.06-0.59) in adolescence within MCS. Being male, having higher self-esteem, greater social support, and a more positive parent-child relationship were associated with fewer total problems (estimates = -0.09 - 1.87) and internalizing difficulties (estimates = -0.03 - 1.88) at age 17 in the full sample regardless of neighborhood deprivation exposure. However, interactions revealed that higher self-esteem was especially beneficial for children exposed to high neighborhood deprivation (estimate = -0.35, 95% CI = -0.43 - 0.27). No significant associations between childhood neighborhood deprivation and adolescent mental health symptoms were found in E-Risk. Interventions focused on improving self-esteem, social support, and parenting may help promote better adolescent mental health in the general population. Those living in the most deprived areas may benefit most from increased self-esteem.",

author = "Rachel Latham and Louise Arseneault and George Ploubidis and Jayati Das-Munshi and Dario Moreno-Agostino and Ioannis Bakolis and Flora Blangis and Fisher, {Helen L.}",

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AU - Arseneault, Louise

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AU - Moreno-Agostino, Dario

AU - Bakolis, Ioannis

AU - Blangis, Flora

AU - Fisher, Helen L.

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N2 - This study investigated associations between childhood neighborhood deprivation and adolescent mental health difficulties, and potential protective factors. Data were utilized from the Millennium Cohort Study (MCS) (born in 2000-2002; N = 5,422; 52% female) and the Environmental Risk (E-Risk) Longitudinal Twin Study (born in 1994-1995; N = 1,920; 53% female). Childhood neighborhood deprivation was measured using the Index of Multiple Deprivation between age 9 months and 14 years (MCS) and at age 12 (E-Risk). Adolescent mental health was assessed using the Strengths and Difficulties Questionnaire at age 17 (MCS) and the Diagnostic Interview Schedule conducted at age 18 with symptoms loading onto general psychopathology, internalizing and externalizing factors (E-Risk). Cross-classified models showed high levels of neighborhood deprivation in childhood were associated with more total problems (estimate = 0.46, 95% CI = 0.04-0.88) and internalizing difficulties (estimate = 0.32, 95% CI = 0.06-0.59) in adolescence within MCS. Being male, having higher self-esteem, greater social support, and a more positive parent-child relationship were associated with fewer total problems (estimates = -0.09 - 1.87) and internalizing difficulties (estimates = -0.03 - 1.88) at age 17 in the full sample regardless of neighborhood deprivation exposure. However, interactions revealed that higher self-esteem was especially beneficial for children exposed to high neighborhood deprivation (estimate = -0.35, 95% CI = -0.43 - 0.27). No significant associations between childhood neighborhood deprivation and adolescent mental health symptoms were found in E-Risk. Interventions focused on improving self-esteem, social support, and parenting may help promote better adolescent mental health in the general population. Those living in the most deprived areas may benefit most from increased self-esteem.

AB - This study investigated associations between childhood neighborhood deprivation and adolescent mental health difficulties, and potential protective factors. Data were utilized from the Millennium Cohort Study (MCS) (born in 2000-2002; N = 5,422; 52% female) and the Environmental Risk (E-Risk) Longitudinal Twin Study (born in 1994-1995; N = 1,920; 53% female). Childhood neighborhood deprivation was measured using the Index of Multiple Deprivation between age 9 months and 14 years (MCS) and at age 12 (E-Risk). Adolescent mental health was assessed using the Strengths and Difficulties Questionnaire at age 17 (MCS) and the Diagnostic Interview Schedule conducted at age 18 with symptoms loading onto general psychopathology, internalizing and externalizing factors (E-Risk). Cross-classified models showed high levels of neighborhood deprivation in childhood were associated with more total problems (estimate = 0.46, 95% CI = 0.04-0.88) and internalizing difficulties (estimate = 0.32, 95% CI = 0.06-0.59) in adolescence within MCS. Being male, having higher self-esteem, greater social support, and a more positive parent-child relationship were associated with fewer total problems (estimates = -0.09 - 1.87) and internalizing difficulties (estimates = -0.03 - 1.88) at age 17 in the full sample regardless of neighborhood deprivation exposure. However, interactions revealed that higher self-esteem was especially beneficial for children exposed to high neighborhood deprivation (estimate = -0.35, 95% CI = -0.43 - 0.27). No significant associations between childhood neighborhood deprivation and adolescent mental health symptoms were found in E-Risk. Interventions focused on improving self-esteem, social support, and parenting may help promote better adolescent mental health in the general population. Those living in the most deprived areas may benefit most from increased self-esteem.

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DO - 10.1017/S0954579425000203

M3 - Article

SN - 0954-5794

JO - Development and Psychopathology

JF - Development and Psychopathology

ER -

Understanding and mitigating associations between childhood neighborhood deprivation and adolescent mental health in two UK birth cohorts

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