Understanding fibroblast heterogeneity in the skin

TY - JOUR

T1 - Understanding fibroblast heterogeneity in the skin

AU - Driskell, Ryan R

AU - Watt, Fiona M

PY - 2014

Y1 - 2014

N2 - Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals, fibroblasts are highly responsive to Wnt-regulated signals from the overlying epidermis, which can act both locally, via extracellular matrix (ECM) deposition, and via secreted factors that impact the behaviour of fibroblasts in different dermal locations. These findings may explain some of the changes that occur in connective tissue during wound healing and cancer progression.

AB - Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals, fibroblasts are highly responsive to Wnt-regulated signals from the overlying epidermis, which can act both locally, via extracellular matrix (ECM) deposition, and via secreted factors that impact the behaviour of fibroblasts in different dermal locations. These findings may explain some of the changes that occur in connective tissue during wound healing and cancer progression.

U2 - 10.1016/j.tcb.2014.10.001

DO - 10.1016/j.tcb.2014.10.001

M3 - Article

C2 - 25455110

SN - 1879-3088

JO - Trends in cell biology

JF - Trends in cell biology

ER -