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Understanding Human Epidermal Stem Cells at Single-Cell Resolution

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)2061-2067
Number of pages7
JournalJournal of Investigative Dermatology
Volume142
Issue number8
Early online date12 May 2022
DOIs
E-pub ahead of print12 May 2022
PublishedAug 2022

Bibliographical note

Funding Information: We gratefully acknowledge the advice and practical contributions of members of the wattlab, past and present. This work was supported by grants to FMW from the United Kingdom Medical Research Council ( MR/PO18823/1 ) and the Wellcome Trust ( 206439/Z/17/Z ; WT211276/Z/18/Z ). VAN is the recipient of a National Council for Scientific and Technological Development-Brazil doctoral scholarship. FMW also acknowledges funding from the Department of Health through the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust. Funding Information: We gratefully acknowledge the advice and practical contributions of members of the wattlab, past and present. This work was supported by grants to FMW from the United Kingdom Medical Research Council (MR/PO18823/1) and the Wellcome Trust (206439/Z/17/Z; WT211276/Z/18/Z). VAN is the recipient of a National Council for Scientific and Technological Development-Brazil doctoral scholarship. FMW also acknowledges funding from the Department of Health through the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's & St Thomas’ NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust. Conceptualization: FMW; Data Curation: VAN; Formal Analysis: VAN; Funding Acquisition: FMW; Investigation: VAN, FMW; Methodology: VAN, FMW; Project Administration: FMW; Resources: FMW; Software: VAN; Supervision: FMW; Validation: VAN, FMW; Visualization: VAN; Writing - Original Draft Preparation: FMW; Writing - Review & Editing: VAN, FMW Funding Information: FMW receives research funding from Unilever and POLA. Publisher Copyright: © 2022 The Authors

King's Authors

Abstract

The human epidermis is one of the first tissues in which the existence of stem cells was recognized and is one of the few in which ex vivo expansion for tissue repair is established clinically. Nevertheless, the nature of stem cells has been elusive. Using clonal growth assays of cultured keratinocytes as a quantitative measure of their abundance, several candidate stem cell markers have been described. Recently, the volume and quality of single-cell RNA-sequencing datasets have increased exponentially, providing new opportunities to explore the nature of epidermal stem cells and test the validity of in vitro experimental models.

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