Understanding psychosis complexity through a syndemic framework: A systematic review

Uzma Zahid, Erin grace Lawrence, Daniela fonseca De freitas, Lois a. Parri, Wesley Quadros, Phuong Hua, Eli Harriss, Dominic Oliver, Georgina m. Hosang, Kamaldeep Bhui

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Psychotic conditions pose significant challenges due to their complex aetiology and impact on individuals and communities. Syndemic theory offers a promising framework to understand the interconnectedness of various health and social problems in the context of psychosis. This systematic review aims to examine existing literature on testing whether psychosis is better understood as a component of a syndemic. We conducted a systematic search of 7 databases, resulting in the inclusion of five original articles. Findings from these studies indicate a syndemic characterized by the coexistence of various health and social conditions, are associated with a greater risk of psychosis, adverse health outcomes, and disparities, especially among ethnic minorities and deprived populations. This review underscores the compelling need for a new paradigm and datasets that can investigate how psychosis emerges in the context of a syndemic, ultimately guiding more effective preventive and care interventions as well as policies to improve the health of marginalised communities living in precarity.
Original languageEnglish
Article number105614
JournalNeuroscience and Biobehavioral Reviews
Early online date10 Mar 2024
Publication statusPublished - 1 Apr 2024


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