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Understanding the development of the respiratory glands

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)525-539
Number of pages15
JournalDevelopmental Dynamics
Volume244
Issue number4
Early online date26 Mar 2015
DOIs
Accepted/In press11 Dec 2014
E-pub ahead of print26 Mar 2015
Published1 Apr 2015

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King's Authors

Abstract

Background: The submucosal glands (SMGs) of the respiratory system are specialized structures essential for maintaining airway homeostasis. The significance of SMGs is highlighted by their involvement in respiratory diseases such as cystic fibrosis, asthma and chronic bronchitis, where their phenotype and function are severely altered. Uncovering the normal development of the airway SMGs is essential to elucidate their role in these disorders, however, very little is known about the cellular mechanisms and intracellular signals involved in their morphogenesis. Results: This review describes in detail the embryonic developmental journey of the nasal SMGs and the postnatal development of the tracheal SMGs in the mouse. Current knowledge of the genes and signalling molecules involved in SMG organogenesis is also explored. Conclusion: Here we review the temporal localisation and development of the murine respiratory glands in the hope of stimulating further research into the mechanisms required for successful SMG patterning and function.

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