TY - JOUR
T1 - Understanding the role of mechanics in nucleocytoplasmic transport
AU - Andreu, Ion
AU - Granero-Moya, Ignasi
AU - Garcia-Manyes, Sergi
AU - Roca-Cusachs, Pere
N1 - Funding Information:
We acknowledge funding from the Spanish Ministry of Science and Innovation (No. PID2019-110298GB-I00), the European Commission (H2020-FETPROACT-01-2016-731957), the Generalitat de Catalunya (2017-SGR-1602), the prize “ICREA Academia” for excellence in research to P.R.-C., Fundació la Marató de TV3 (No. 201936-30-31), and the “la Caixa” Foundation (grant LCF/PR/HR20/52400004 and fellowship LCF/BQ/DE18/11670010 to I.G.-M.). The Francis Crick Institute which receives its core funding from Cancer Research U.K. (No. FC001002), the U.K. Medical Research Council (No. FC001002), and the Wellcome Trust (No. FC001002). S.G.M. acknowledges BBSRC sLOLA (No. BB/V003518/1), Leverhulme Trust Research Leadership Award No. RL 2016–015, Wellcome Trust Investigator Award No. 212218/Z/ 18/Z, and Royal Society Wolfson Fellowship No. RSWF/R3/183006. IBEC is a recipient of a Severo Ochoa Award of Excellence from MINCIN.
Publisher Copyright:
© 2022 Author(s).
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs). Mechanical regulation occurs at two levels: first, by force application to the nucleus, which increases NPC permeability likely through NPC stretch. Second, by the mechanical properties of the transported proteins themselves, as mechanically labile proteins translocate through NPCs faster than mechanically stiff ones. In this perspective, we discuss this evidence and the associated mechanisms by which mechanics can regulate the nucleo-cytoplasmic partitioning of proteins. Finally, we analyze how mechanical regulation of nucleocytoplasmic transport can provide a systematic approach to the study of mechanobiology and open new avenues both in fundamental and applied research.
AB - Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs). Mechanical regulation occurs at two levels: first, by force application to the nucleus, which increases NPC permeability likely through NPC stretch. Second, by the mechanical properties of the transported proteins themselves, as mechanically labile proteins translocate through NPCs faster than mechanically stiff ones. In this perspective, we discuss this evidence and the associated mechanisms by which mechanics can regulate the nucleo-cytoplasmic partitioning of proteins. Finally, we analyze how mechanical regulation of nucleocytoplasmic transport can provide a systematic approach to the study of mechanobiology and open new avenues both in fundamental and applied research.
UR - http://www.scopus.com/inward/record.url?scp=85133729422&partnerID=8YFLogxK
U2 - 10.1063/5.0076034
DO - 10.1063/5.0076034
M3 - Article
AN - SCOPUS:85133729422
SN - 2473-2877
VL - 6
JO - APL Bioengineering
JF - APL Bioengineering
IS - 2
M1 - 020901
ER -