Unlocking the non-invasive assessment of conduit and reservoir function in the aorta: The obstructive descending aorta in HLHS

Adelaide De Vecchi; Alessandro Faraci; Joao Filipe Cardoso Pires Timoteo Fernandes; David Marlevi; Hannah R. Bellsham-Revell; Tarique Hussain; Nidhin Laji; Bram Ruijsink; James Wong; Reza Razavi; David Anderson; Caner Salih; Kuberan Pushparajah; David Nordsletten; Pablo Lamata de la Orden

doi:10.1007/s12265-022-10221-4

Unlocking the non-invasive assessment of conduit and reservoir function in the aorta: The obstructive descending aorta in HLHS

Adelaide De Vecchi, Alessandro Faraci, Joao Filipe Cardoso Pires Timoteo Fernandes, David Marlevi, Hannah R. Bellsham-Revell, Tarique Hussain, Nidhin Laji, Bram Ruijsink, James Wong, Reza Razavi, David Anderson, Caner Salih, Kuberan Pushparajah, David Nordsletten, Pablo Lamata de la Orden^*

^*Corresponding author for this work

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Abstract

Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract: [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	1075-1085
Number of pages	11
Journal	Journal of cardiovascular translational research
Volume	15
Issue number	5
Early online date	23 Feb 2022
DOIs	https://doi.org/10.1007/s12265-022-10221-4
Publication status	Published - Oct 2022

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De Vecchi, A., Faraci, A., Cardoso Pires Timoteo Fernandes, J. F., Marlevi, D., Bellsham-Revell, H. R., Hussain, T., Laji, N., Ruijsink, B., Wong, J., Razavi, R., Anderson, D., Salih, C., Pushparajah, K., Nordsletten, D., & Lamata de la Orden, P. (2022). Unlocking the non-invasive assessment of conduit and reservoir function in the aorta: The obstructive descending aorta in HLHS. Journal of cardiovascular translational research, 15(5), 1075-1085. https://doi.org/10.1007/s12265-022-10221-4

@article{0ef038be27514d1b927491d36cb79a92,

title = "Unlocking the non-invasive assessment of conduit and reservoir function in the aorta: The obstructive descending aorta in HLHS",

abstract = "Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract: [Figure not available: see fulltext.].",

author = "{De Vecchi}, Adelaide and Alessandro Faraci and {Cardoso Pires Timoteo Fernandes}, {Joao Filipe} and David Marlevi and Bellsham-Revell, {Hannah R.} and Tarique Hussain and Nidhin Laji and Bram Ruijsink and James Wong and Reza Razavi and David Anderson and Caner Salih and Kuberan Pushparajah and David Nordsletten and {Lamata de la Orden}, Pablo",

note = "Funding Information: This work was supported by Action Medical Research project grant GN2401, the Wellcome/EPSRC Centre for Medical Engineering (WT 203,148/Z/16/Z), by the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No 764738 and by the National Institute for Health Research (NIHR) Cardiovascular MedTech Co-operative. PL holds a Wellcome Trust Senior Research Fellowship (209,450/Z/17/Z). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = oct,

doi = "10.1007/s12265-022-10221-4",

language = "English",

volume = "15",

pages = "1075--1085",

journal = "Journal of cardiovascular translational research",

issn = "1937-5387",

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De Vecchi, A , Faraci, A , Cardoso Pires Timoteo Fernandes, JF, Marlevi, D, Bellsham-Revell, HR, Hussain, T, Laji, N, Ruijsink, B, Wong, J , Razavi, R , Anderson, D , Salih, C , Pushparajah, K , Nordsletten, D & Lamata de la Orden, P 2022, 'Unlocking the non-invasive assessment of conduit and reservoir function in the aorta: The obstructive descending aorta in HLHS', Journal of cardiovascular translational research, vol. 15, no. 5, pp. 1075-1085. https://doi.org/10.1007/s12265-022-10221-4

Unlocking the non-invasive assessment of conduit and reservoir function in the aorta: The obstructive descending aorta in HLHS. / De Vecchi, Adelaide ; Faraci, Alessandro ; Cardoso Pires Timoteo Fernandes, Joao Filipe et al.
In: Journal of cardiovascular translational research, Vol. 15, No. 5, 10.2022, p. 1075-1085.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Unlocking the non-invasive assessment of conduit and reservoir function in the aorta

T2 - The obstructive descending aorta in HLHS

AU - De Vecchi, Adelaide

AU - Faraci, Alessandro

AU - Cardoso Pires Timoteo Fernandes, Joao Filipe

AU - Marlevi, David

AU - Bellsham-Revell, Hannah R.

AU - Hussain, Tarique

AU - Laji, Nidhin

AU - Ruijsink, Bram

AU - Wong, James

AU - Razavi, Reza

AU - Anderson, David

AU - Salih, Caner

AU - Pushparajah, Kuberan

AU - Nordsletten, David

AU - Lamata de la Orden, Pablo

N1 - Funding Information: This work was supported by Action Medical Research project grant GN2401, the Wellcome/EPSRC Centre for Medical Engineering (WT 203,148/Z/16/Z), by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 764738 and by the National Institute for Health Research (NIHR) Cardiovascular MedTech Co-operative. PL holds a Wellcome Trust Senior Research Fellowship (209,450/Z/17/Z). Publisher Copyright: © 2022, The Author(s).

PY - 2022/10

Y1 - 2022/10

N2 - Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract: [Figure not available: see fulltext.].

AB - Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract: [Figure not available: see fulltext.].

UR - http://www.scopus.com/inward/record.url?scp=85125085361&partnerID=8YFLogxK

U2 - 10.1007/s12265-022-10221-4

DO - 10.1007/s12265-022-10221-4

M3 - Article

SN - 1937-5387

VL - 15

SP - 1075

EP - 1085

JO - Journal of cardiovascular translational research

JF - Journal of cardiovascular translational research

IS - 5

ER -

Unlocking the non-invasive assessment of conduit and reservoir function in the aorta: The obstructive descending aorta in HLHS

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