Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

E Levantini; A Giorgetti; F Cerisoli; E Traggiai; A Guidi; R Martin; D Acampora; P D Aplan; G Keller; A Simeone; N N Iscove; T Hoang; M C Magli

doi:10.1073/pnas.1734071100

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

E Levantini, A Giorgetti, F Cerisoli, E Traggiai, A Guidi, R Martin, D Acampora, P D Aplan, G Keller, A Simeone, N N Iscove, T Hoang, M C Magli

King's College London

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1(-/-) mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.

Original language	English
Pages (from-to)	10299 - 10303
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	100
Issue number	18
DOIs	https://doi.org/10.1073/pnas.1734071100
Publication status	Published - 2 Sept 2003

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Levantini, E., Giorgetti, A., Cerisoli, F., Traggiai, E., Guidi, A., Martin, R., Acampora, D., Aplan, P. D., Keller, G., Simeone, A., Iscove, N. N., Hoang, T., & Magli, M. C. (2003). Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America, 100(18), 10299 - 10303. https://doi.org/10.1073/pnas.1734071100

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abstract = "Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1(-/-) mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.",

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Levantini, E, Giorgetti, A, Cerisoli, F, Traggiai, E, Guidi, A, Martin, R, Acampora, D, Aplan, PD, Keller, G, Simeone, A, Iscove, NN, Hoang, T & Magli, MC 2003, 'Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 18, pp. 10299 - 10303. https://doi.org/10.1073/pnas.1734071100

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T1 - Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

AU - Levantini, E

AU - Giorgetti, A

AU - Cerisoli, F

AU - Traggiai, E

AU - Guidi, A

AU - Martin, R

AU - Acampora, D

AU - Aplan, P D

AU - Keller, G

AU - Simeone, A

AU - Iscove, N N

AU - Hoang, T

AU - Magli, M C

PY - 2003/9/2

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AB - Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1(-/-) mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.

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DO - 10.1073/pnas.1734071100

M3 - Article

SN - 1091-6490

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EP - 10303

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 18

ER -

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

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