Update of the risk assessment of inorganic arsenic in food

Dieter Schrenk; Margherita Bignami; Laurent Bodin; James Kevin Chipman; Jesús del Mazo; Bettina Grasl-Kraupp; Christer Hogstrand; Laurentius (Ron) Hoogenboom; Jean-Charles Leblanc; Carlo Stefano Nebbia; Elsa Nielsen; Evangelia Ntzani; Annette Petersen; Salomon Sand; Christiane Vleminckx; Heather Wallace; Lars Barregård; Diane Benford; Karin Broberg; Eugenia Dogliotti; Tony Fletcher; Lars Rylander; José Cortiñas Abrahantes; Jose Ángel Gómez Ruiz; Hans Steinkellner; Tuuli Tauriainen; Tanja Schwerdtle

doi:10.2903/j.efsa.2024.8488

Update of the risk assessment of inorganic arsenic in food

Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean-Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Christiane Vleminckx, Heather Wallace, Lars Barregård, Diane Benford, Karin Broberg, Eugenia DogliottiTony Fletcher, Lars Rylander, José Cortiñas Abrahantes, Jose Ángel Gómez Ruiz, Hans Steinkellner, Tuuli Tauriainen, Tanja Schwerdtle

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL ₀₅) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.

Original language	English
Article number	e8488
Pages (from-to)	e8488
Journal	EFSA Journal
Volume	22
Issue number	1
DOIs	https://doi.org/10.2903/j.efsa.2024.8488
Publication status	Published - Jan 2024

Keywords

benchmark dose (BMD)
epidemiological studies
inorganic arsenic (iAs)
margin of exposure (MOE)
risk assessment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2903/j.efsa.2024.8488

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Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L., Leblanc, J.-C., Nebbia, C. S., Nielsen, E., Ntzani, E., Petersen, A., Sand, S., Vleminckx, C., Wallace, H., Barregård, L., Benford, D., Broberg, K., ... Schwerdtle, T. (2024). Update of the risk assessment of inorganic arsenic in food. EFSA Journal, 22(1), e8488. Article e8488. https://doi.org/10.2903/j.efsa.2024.8488

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title = "Update of the risk assessment of inorganic arsenic in food",

abstract = "The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL 05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.",

keywords = "benchmark dose (BMD), epidemiological studies, inorganic arsenic (iAs), margin of exposure (MOE), risk assessment",

author = "Dieter Schrenk and Margherita Bignami and Laurent Bodin and Chipman, {James Kevin} and {del Mazo}, Jes{\'u}s and Bettina Grasl-Kraupp and Christer Hogstrand and Hoogenboom, {Laurentius (Ron)} and Jean-Charles Leblanc and Nebbia, {Carlo Stefano} and Elsa Nielsen and Evangelia Ntzani and Annette Petersen and Salomon Sand and Christiane Vleminckx and Heather Wallace and Lars Barreg{\aa}rd and Diane Benford and Karin Broberg and Eugenia Dogliotti and Tony Fletcher and Lars Rylander and Abrahantes, {Jos{\'e} Corti{\~n}as} and G{\'o}mez Ruiz, {Jose {\'A}ngel} and Hans Steinkellner and Tuuli Tauriainen and Tanja Schwerdtle",

note = "Publisher Copyright: {\textcopyright} 2024 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH on behalf of European Food Safety Authority.",

year = "2024",

month = jan,

doi = "10.2903/j.efsa.2024.8488",

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Schrenk, D, Bignami, M, Bodin, L, Chipman, JK, del Mazo, J, Grasl-Kraupp, B, Hogstrand, C, Hoogenboom, L, Leblanc, J-C, Nebbia, CS, Nielsen, E, Ntzani, E, Petersen, A, Sand, S, Vleminckx, C, Wallace, H, Barregård, L, Benford, D, Broberg, K, Dogliotti, E, Fletcher, T, Rylander, L, Abrahantes, JC, Gómez Ruiz, JÁ, Steinkellner, H, Tauriainen, T & Schwerdtle, T 2024, 'Update of the risk assessment of inorganic arsenic in food', EFSA Journal, vol. 22, no. 1, e8488, pp. e8488. https://doi.org/10.2903/j.efsa.2024.8488

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AU - Bignami, Margherita

AU - Bodin, Laurent

AU - Chipman, James Kevin

AU - del Mazo, Jesús

AU - Grasl-Kraupp, Bettina

AU - Hogstrand, Christer

AU - Hoogenboom, Laurentius (Ron)

AU - Leblanc, Jean-Charles

AU - Nebbia, Carlo Stefano

AU - Nielsen, Elsa

AU - Ntzani, Evangelia

AU - Petersen, Annette

AU - Sand, Salomon

AU - Vleminckx, Christiane

AU - Wallace, Heather

AU - Barregård, Lars

AU - Benford, Diane

AU - Broberg, Karin

AU - Dogliotti, Eugenia

AU - Fletcher, Tony

AU - Rylander, Lars

AU - Abrahantes, José Cortiñas

AU - Gómez Ruiz, Jose Ángel

AU - Steinkellner, Hans

AU - Tauriainen, Tuuli

AU - Schwerdtle, Tanja

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Update of the risk assessment of inorganic arsenic in food

Abstract

Keywords

UN SDGs

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