Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Dieter Schrenk; Margherita Bignami; Laurent Bodin; James Kevin Chipman; Jesús del Mazo; Bettina Grasl-Kraupp; Christer Hogstrand; Laurentius (Ron) Hoogenboom; Jean-Charles Leblanc; Carlo Stefano Nebbia; Elsa Nielsen; Evangelia Ntzani; Annette Petersen; Salomon Sand; Tanja Schwerdtle; Heather Wallace; Diane Benford; Peter Fürst; Andy Hart; Martin Rose; Henri Schroeder; Martine Vrijheid; Sofia Ioannidou; Marina Nikolič; Luisa Ramos Bordajandi; Christiane Vleminckx

doi:10.2903/j.efsa.2024.8497

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean-Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Heather Wallace, Diane Benford, Peter Fürst, Andy Hart, Martin RoseHenri Schroeder, Martine Vrijheid, Sofia Ioannidou, Marina Nikolič, Luisa Ramos Bordajandi, Christiane Vleminckx

King's College London

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE-28, -47, -49, -99, -100, -138, -153, -154, -183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE-47, -99, -153, -209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint-specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

Original language	English
Article number	e8497
Pages (from-to)	e8497
Journal	EFSA Journal
Volume	22
Issue number	1
DOIs	https://doi.org/10.2903/j.efsa.2024.8497
Publication status	Published - Jan 2024

Keywords

food
human exposure
occurrence
PBDEs
Polybrominated diphenyl ethers
risk assessment
toxicology

Access to Document

10.2903/j.efsa.2024.8497

Cite this

Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl-Kraupp, B., Hogstrand, C., (Ron) Hoogenboom, L., Leblanc, J.-C., Nebbia, C. S., Nielsen, E., Ntzani, E., Petersen, A., Sand, S., Schwerdtle, T., Wallace, H., Benford, D., Fürst, P., Hart, A., ... Vleminckx, C. (2024). Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food. EFSA Journal, 22(1), e8497. Article e8497. https://doi.org/10.2903/j.efsa.2024.8497

@article{597b6356604e41558b2a4dd45f04c6d3,

title = "Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food",

abstract = "The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE-28, -47, -49, -99, -100, -138, -153, -154, -183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE-47, -99, -153, -209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint-specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.",

keywords = "food, human exposure, occurrence, PBDEs, Polybrominated diphenyl ethers, risk assessment, toxicology",

author = "Dieter Schrenk and Margherita Bignami and Laurent Bodin and Chipman, {James Kevin} and {del Mazo}, Jes{\'u}s and Bettina Grasl-Kraupp and Christer Hogstrand and Laurentius (Ron) Hoogenboom and Jean-Charles Leblanc and Nebbia, {Carlo Stefano} and Elsa Nielsen and Evangelia Ntzani and Annette Petersen and Salomon Sand and Tanja Schwerdtle and Heather Wallace and Diane Benford and Peter F{\"u}rst and Andy Hart and Martin Rose and Henri Schroeder and Martine Vrijheid and Sofia Ioannidou and Marina Nikoli{\v c} and Bordajandi, {Luisa Ramos} and Christiane Vleminckx",

note = "Publisher Copyright: {\textcopyright} 2024 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH on behalf of European Food Safety Authority.",

year = "2024",

month = jan,

doi = "10.2903/j.efsa.2024.8497",

language = "English",

volume = "22",

pages = "e8497",

journal = "EFSA Journal",

issn = "1831-4732",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

Schrenk, D, Bignami, M, Bodin, L, Chipman, JK, del Mazo, J, Grasl-Kraupp, B, Hogstrand, C, (Ron) Hoogenboom, L, Leblanc, J-C, Nebbia, CS, Nielsen, E, Ntzani, E, Petersen, A, Sand, S, Schwerdtle, T, Wallace, H, Benford, D, Fürst, P, Hart, A, Rose, M, Schroeder, H, Vrijheid, M, Ioannidou, S, Nikolič, M, Bordajandi, LR & Vleminckx, C 2024, 'Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food', EFSA Journal, vol. 22, no. 1, e8497, pp. e8497. https://doi.org/10.2903/j.efsa.2024.8497

TY - JOUR

T1 - Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

AU - Schrenk, Dieter

AU - Bignami, Margherita

AU - Bodin, Laurent

AU - Chipman, James Kevin

AU - del Mazo, Jesús

AU - Grasl-Kraupp, Bettina

AU - Hogstrand, Christer

AU - (Ron) Hoogenboom, Laurentius

AU - Leblanc, Jean-Charles

AU - Nebbia, Carlo Stefano

AU - Nielsen, Elsa

AU - Ntzani, Evangelia

AU - Petersen, Annette

AU - Sand, Salomon

AU - Schwerdtle, Tanja

AU - Wallace, Heather

AU - Benford, Diane

AU - Fürst, Peter

AU - Hart, Andy

AU - Rose, Martin

AU - Schroeder, Henri

AU - Vrijheid, Martine

AU - Ioannidou, Sofia

AU - Nikolič, Marina

AU - Bordajandi, Luisa Ramos

AU - Vleminckx, Christiane

PY - 2024/1

Y1 - 2024/1

N2 - The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE-28, -47, -49, -99, -100, -138, -153, -154, -183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE-47, -99, -153, -209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint-specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

AB - The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE-28, -47, -49, -99, -100, -138, -153, -154, -183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE-47, -99, -153, -209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint-specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

KW - food

KW - human exposure

KW - occurrence

KW - PBDEs

KW - Polybrominated diphenyl ethers

KW - risk assessment

KW - toxicology

UR - http://www.scopus.com/inward/record.url?scp=85182997041&partnerID=8YFLogxK

U2 - 10.2903/j.efsa.2024.8497

DO - 10.2903/j.efsa.2024.8497

M3 - Article

SN - 1831-4732

VL - 22

SP - e8497

JO - EFSA Journal

JF - EFSA Journal

IS - 1

M1 - e8497

ER -

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this