Update on psoriasis immunopathogenesis and targeted immunotherapy

Satveer K Mahil, Francesca Capon, Jonathan N Barker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

159 Citations (Scopus)
200 Downloads (Pure)

Abstract

Over recent years, significant progress has been made in characterisation of the underlying pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with major systemic co-morbidity and reduced life expectancy. Basic science discoveries have informed the design of novel therapeutic approaches, many of which are now under evaluation in late-stage clinical trials. Here we describe the complex interplay between immune cell types and cytokine networks that acts within self-perpetuating feedback loops to drive cutaneous inflammation in psoriasis. Genetic studies have been pivotal in the construction of the disease model and more recently have uncovered a distinct aetiology for rare, pustular variants of psoriasis. The translation of mechanistic insights into potential advancements in clinical care will also be described, including several treatments that target the interleukin-23 (IL-23)/T17 immune axis.

Original languageEnglish
Pages (from-to)11-27
JournalSeminars In Immunopathology
Volume38
Issue number1
DOIs
Publication statusPublished - 16 Nov 2015

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