Update on the assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form-2 (ATHF-SF2)

TY - JOUR

T1 - Update on the assessment of resistance to antidepressant treatment

T2 - Rationale for the Antidepressant Treatment History Form: Short Form-2 (ATHF-SF2)

AU - Sackeim, Harold A

AU - Aaronson, Scott T

AU - Bunker, Mark T

AU - Conway, Charles R

AU - George, Mark S

AU - McAlister-Williams, R Hamish

AU - Prudic, Joan

AU - Thase, Michael E

AU - Young, Allan H

AU - Rush, A John

N1 - Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2024/8

Y1 - 2024/8

N2 - All definitions of treatment-resistant depression (TRD) require that patients have experienced insufficient benefit from one or more adequate antidepressant trials. Thus, identifying "failed, adequate trials" is key to the assessment of TRD. The Antidepressant Treatment History Form (ATHF) was one of the first and most widely used instruments that provided objective criteria in making these assessments. The original ATHF was updated in 2018 to the ATHF-SF, changing to a checklist format for scoring, and including specific pharmacotherapy, brain stimulation, and psychotherapy interventions as potentially adequate antidepressant treatments. The ATHF-SF2, presented here, is based on the consensus of the ATHF workgroup about the novel interventions introduced since the last revision and which should/should not be considered effective treatments for major depressive episodes. This document describes the rationale for these choices and, for each intervention, the minimal criteria for determining the adequacy of treatment administration. The Supplementary Material that accompanies this article provide the Scoring Checklist, Data Collection Forms (current episode and composite of previous episodes), and Instruction Manual for the ATHF-SF2.

AB - All definitions of treatment-resistant depression (TRD) require that patients have experienced insufficient benefit from one or more adequate antidepressant trials. Thus, identifying "failed, adequate trials" is key to the assessment of TRD. The Antidepressant Treatment History Form (ATHF) was one of the first and most widely used instruments that provided objective criteria in making these assessments. The original ATHF was updated in 2018 to the ATHF-SF, changing to a checklist format for scoring, and including specific pharmacotherapy, brain stimulation, and psychotherapy interventions as potentially adequate antidepressant treatments. The ATHF-SF2, presented here, is based on the consensus of the ATHF workgroup about the novel interventions introduced since the last revision and which should/should not be considered effective treatments for major depressive episodes. This document describes the rationale for these choices and, for each intervention, the minimal criteria for determining the adequacy of treatment administration. The Supplementary Material that accompanies this article provide the Scoring Checklist, Data Collection Forms (current episode and composite of previous episodes), and Instruction Manual for the ATHF-SF2.

UR - http://www.scopus.com/inward/record.url?scp=85196672918&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychires.2024.05.046

DO - 10.1016/j.jpsychires.2024.05.046

M3 - Review article

C2 - 38917723

SN - 0022-3956

VL - 176

SP - 325

EP - 337

JO - Journal of psychiatric research

JF - Journal of psychiatric research

ER -