Urine Bile Acids Relate to Glucose Control in Patients with Type 2 Diabetes Mellitus and a Body Mass Index Below 30 kg/m(2)

TY - JOUR

T1 - Urine Bile Acids Relate to Glucose Control in Patients with Type 2 Diabetes Mellitus and a Body Mass Index Below 30 kg/m(2)

AU - Taylor, David R.

AU - Alaghband-Zadeh, Jamshid

AU - Cross, Gemma F.

AU - Omar, Sohail

AU - le Roux, Carel W.

AU - Vincent, Royce

PY - 2014/4/15

Y1 - 2014/4/15

N2 - Bile acids are important endocrine signalling molecules, modulating glucose homeostasis through activation of cell surface and nuclear receptors. Bile acid metabolism is altered in type 2 diabetes mellitus; however, whether this is of pathogenic consequence is not fully established. In this study urinary bile acid excretion in individuals with type 2 diabetes and matched healthy volunteers was assessed. Urinary bile acid excretion in type 2 diabetes patients was considered in the context of prevailing glycaemia and the patient body mass index. Urine bile acids were measured by liquid chromatography-tandem mass spectrometry, allowing individual quantification of 15 bile acid species. Urinary bile acid excretion in patients with type 2 diabetes who were normal weight (BMI 18.5-24.9 kg/m(2)) and overweight (BMI 25-29.9 kg/m(2)) were elevated compared to healthy normal weight volunteers, both p= 30 kg/m(2)) type 2 diabetes patients, urinary bile acid excretion was significantly lower than in the normal and overweight type 2 diabetes groups (both p

AB - Bile acids are important endocrine signalling molecules, modulating glucose homeostasis through activation of cell surface and nuclear receptors. Bile acid metabolism is altered in type 2 diabetes mellitus; however, whether this is of pathogenic consequence is not fully established. In this study urinary bile acid excretion in individuals with type 2 diabetes and matched healthy volunteers was assessed. Urinary bile acid excretion in type 2 diabetes patients was considered in the context of prevailing glycaemia and the patient body mass index. Urine bile acids were measured by liquid chromatography-tandem mass spectrometry, allowing individual quantification of 15 bile acid species. Urinary bile acid excretion in patients with type 2 diabetes who were normal weight (BMI 18.5-24.9 kg/m(2)) and overweight (BMI 25-29.9 kg/m(2)) were elevated compared to healthy normal weight volunteers, both p= 30 kg/m(2)) type 2 diabetes patients, urinary bile acid excretion was significantly lower than in the normal and overweight type 2 diabetes groups (both p

KW - GLUCAGON-LIKE PEPTIDE-1

KW - CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE

KW - PANCREATIC BETA-CELLS

KW - INSULIN-RESISTANCE

KW - BARIATRIC SURGERY

KW - METABOLIC-REGULATION

KW - GASTRIC BYPASS

KW - OBESE SUBJECTS

KW - RECEPTOR FXR

KW - LIFE-STYLE

U2 - 10.1371/journal.pone.0093540

DO - 10.1371/journal.pone.0093540

M3 - Article

SN - 1932-6203

VL - 9

JO - PL o S One

JF - PL o S One

IS - 4

M1 - 93540

ER -