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Using systems biology approaches to elucidate cause and effect in host-microbiome interactions

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)141-146
JournalCurrent Opinion in Systems Biology
Early online date12 May 2017
E-pub ahead of print12 May 2017
PublishedJun 2017


King's Authors


The human microbiome is a diverse and complex ecosystem integral for healthy human development. Recent advances in next-generation sequencing technology have paved the way for a ‘multi-omics’ era of microbiome research, uncovering associations between microbial dysbiosis and disease. Our ability to harness the full potential of these ‘multi- omics’ datasets are currently constrained by several technical, analytical, computational and bioinformatics factors. However, it may be possible to overcome such limitations through the use of novel systems biology thinking and approaches, to integrate and analyse these large ‘multi-omics’ datasets. Thus, the question arises - can systems biology approaches pave the way to a new era in microbiome research; determining underlying mechanisms in health and disease, and identifying key microbial interactions and causalities?

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