Validating the inspired sinewave technique to measure lung heterogeneity compared to atelectasis & over-distended volume in computed tomography images

Minh Tran, Phi Anh Phan, Douglas C Crockett, Federico Formenti, John Cronin, Stephen Payne, Andrew D. Farmery

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The inspired sinewave technique (IST) is a non-invasive nonionising method which can measure accurately lung
parameters. Six anaesthetised pigs were studied after
surfactant depletion by saline-lavage. Paired measurements
of lung heterogeneity were taken with the IST and computed
tomography (CT). Lung heterogeneity measured by the IST
was calculated by the ratio of tracer gas outputs measured at 180s and 60s. In CT images, lungs were manually segmented and divided into different regions according to voxel density.
The IST and CT show strong agreement on lung heterogeneity measurements. In the IST ventilation heterogeneity value, the linear correlation in total of six pigs are weaker than individual animal (R2=0.33 vs R2=0.67 on average). The IST perfusion heterogeneity agreements are lower than IST ventilation values due to the IST technical setup. IST has the potential to measure the lung heterogeneity
in ARDS animals.
Original languageEnglish
Pages (from-to)1010-1014
Number of pages5
JournalIEEE Xplore
Volume2021-June
DOIs
Publication statusPublished - 2021

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